Comparing prognostic utility between the 8th edition of TNM staging system and the lymph node ratio for oral squamous cell carcinoma

Giada A. Beltramini; Laura M. Belloni; Nicola Fusco; Andrea Sacconi; Paola Muti; Alessandro Baj; Alessandro R. Bolzoni; Aldo B. Giannì

doi:10.1002/hed.26769

Comparing prognostic utility between the 8th edition of TNM staging system and the lymph node ratio for oral squamous cell carcinoma

Giada A. Beltramini, Laura M. Belloni, Nicola Fusco, Andrea Sacconi, Paola Muti, Alessandro Baj, Alessandro R. Bolzoni, Aldo B. Giannì

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Lymph node metastasis in oral squamous cell carcinoma (OSCC) is associated with poor prognosis. The 8th edition of TNM has implemented new nodal staging criteria. We assess the prognostic utility of the lymph node ratio (LNR) and compare it to that of pN in the TNM 8th edition. Methods: One hundred and forty-two patients with OSCC were retrospectively studied. Nodal staging was performed using the TMN 8th edition and the prognostic value of the LNR in terms of overall survival (OS) and disease-free survival (DFS) was evaluated. Results: Fifty-seven patients were eligible for inclusion. The LNR was independently prognostic of OS (p = 0.02). Instead N classification was not significantly predictive of OS (p = 0.10). High LNRs resulted in decreases in OS of approximately 40% within 6 months after surgery. Conclusions: The LNR identifies patients with poor outcomes better than N classification. The lack of reliable LNR cutoffs compromises its utility in clinical practice.

Original language	English
Pages (from-to)	2876-2882
Journal	Head and Neck
Volume	43
Issue number	10
DOIs	https://doi.org/10.1002/hed.26769
Publication status	Published - 2021

Keywords

lymph node ratio
neck dissection
neoplasm recurrence
oral cancer
survival

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.26769

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@article{4c49669c7b944d26b1cb9f3cbac84491,

title = "Comparing prognostic utility between the 8th edition of TNM staging system and the lymph node ratio for oral squamous cell carcinoma",

abstract = "Background: Lymph node metastasis in oral squamous cell carcinoma (OSCC) is associated with poor prognosis. The 8th edition of TNM has implemented new nodal staging criteria. We assess the prognostic utility of the lymph node ratio (LNR) and compare it to that of pN in the TNM 8th edition. Methods: One hundred and forty-two patients with OSCC were retrospectively studied. Nodal staging was performed using the TMN 8th edition and the prognostic value of the LNR in terms of overall survival (OS) and disease-free survival (DFS) was evaluated. Results: Fifty-seven patients were eligible for inclusion. The LNR was independently prognostic of OS (p = 0.02). Instead N classification was not significantly predictive of OS (p = 0.10). High LNRs resulted in decreases in OS of approximately 40% within 6 months after surgery. Conclusions: The LNR identifies patients with poor outcomes better than N classification. The lack of reliable LNR cutoffs compromises its utility in clinical practice.",

keywords = "lymph node ratio, neck dissection, neoplasm recurrence, oral cancer, survival",

author = "Beltramini, {Giada A.} and Belloni, {Laura M.} and Nicola Fusco and Andrea Sacconi and Paola Muti and Alessandro Baj and Bolzoni, {Alessandro R.} and Giann{\`i}, {Aldo B.}",

note = "Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

doi = "10.1002/hed.26769",

language = "English",

volume = "43",

pages = "2876--2882",

journal = "Head and Neck Surgery",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

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TY - JOUR

T1 - Comparing prognostic utility between the 8th edition of TNM staging system and the lymph node ratio for oral squamous cell carcinoma

AU - Beltramini, Giada A.

AU - Belloni, Laura M.

AU - Fusco, Nicola

AU - Sacconi, Andrea

AU - Muti, Paola

AU - Baj, Alessandro

AU - Bolzoni, Alessandro R.

AU - Giannì, Aldo B.

PY - 2021

Y1 - 2021

N2 - Background: Lymph node metastasis in oral squamous cell carcinoma (OSCC) is associated with poor prognosis. The 8th edition of TNM has implemented new nodal staging criteria. We assess the prognostic utility of the lymph node ratio (LNR) and compare it to that of pN in the TNM 8th edition. Methods: One hundred and forty-two patients with OSCC were retrospectively studied. Nodal staging was performed using the TMN 8th edition and the prognostic value of the LNR in terms of overall survival (OS) and disease-free survival (DFS) was evaluated. Results: Fifty-seven patients were eligible for inclusion. The LNR was independently prognostic of OS (p = 0.02). Instead N classification was not significantly predictive of OS (p = 0.10). High LNRs resulted in decreases in OS of approximately 40% within 6 months after surgery. Conclusions: The LNR identifies patients with poor outcomes better than N classification. The lack of reliable LNR cutoffs compromises its utility in clinical practice.

AB - Background: Lymph node metastasis in oral squamous cell carcinoma (OSCC) is associated with poor prognosis. The 8th edition of TNM has implemented new nodal staging criteria. We assess the prognostic utility of the lymph node ratio (LNR) and compare it to that of pN in the TNM 8th edition. Methods: One hundred and forty-two patients with OSCC were retrospectively studied. Nodal staging was performed using the TMN 8th edition and the prognostic value of the LNR in terms of overall survival (OS) and disease-free survival (DFS) was evaluated. Results: Fifty-seven patients were eligible for inclusion. The LNR was independently prognostic of OS (p = 0.02). Instead N classification was not significantly predictive of OS (p = 0.10). High LNRs resulted in decreases in OS of approximately 40% within 6 months after surgery. Conclusions: The LNR identifies patients with poor outcomes better than N classification. The lack of reliable LNR cutoffs compromises its utility in clinical practice.

KW - lymph node ratio

KW - neck dissection

KW - neoplasm recurrence

KW - oral cancer

KW - survival

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DO - 10.1002/hed.26769

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SN - 1043-3074

VL - 43

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JO - Head and Neck Surgery

JF - Head and Neck Surgery

IS - 10

ER -

Comparing prognostic utility between the 8th edition of TNM staging system and the lymph node ratio for oral squamous cell carcinoma

Abstract

Keywords

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