Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which Gβ2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.
|Number of pages||15|
|Journal||Journal of Proteome Research|
|Publication status||Published - Jul 2007|
- All-trans-retinoic acid
- Cell line
- Human neuroblastoma
ASJC Scopus subject areas