Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone)

E. Perucca; R. Grimaldi; G. Ruberto; C. Gelmi; F. Trimarchi; A. Crema

doi:10.1007/BF00615968

Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone)

E. Perucca, R. Grimaldi, G. Ruberto, C. Gelmi, F. Trimarchi, A. Crema

Research output: Contribution to journal › Article › peer-review

Abstract

The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.

Original language	English
Pages (from-to)	729-730
Number of pages	2
Journal	European Journal of Clinical Pharmacology
Volume	29
Issue number	6
DOIs	https://doi.org/10.1007/BF00615968
Publication status	Published - Nov 1986

Keywords

barbexaclone
bioavailability
healthy volunteers
pharmacokinetics
phenobarbital
propylhexedrine salt

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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10.1007/BF00615968

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abstract = "The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.",

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author = "E. Perucca and R. Grimaldi and G. Ruberto and C. Gelmi and F. Trimarchi and A. Crema",

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AU - Perucca, E.

AU - Grimaldi, R.

AU - Ruberto, G.

AU - Gelmi, C.

AU - Trimarchi, F.

AU - Crema, A.

PY - 1986/11

Y1 - 1986/11

N2 - The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.

AB - The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.

KW - barbexaclone

KW - bioavailability

KW - healthy volunteers

KW - pharmacokinetics

KW - phenobarbital

KW - propylhexedrine salt

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Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone)

Abstract

Keywords

ASJC Scopus subject areas

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