Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Aurelia Santoro, Elisa Pini, Maria Scurti, Giustina Palmas, Agnes Berendsen, Anna Brzozowska, Barbara Pietruszka, Anna Szczecinska, Noël Cano, Nathalie Meunier, C. P G M de Groot, Edith Feskens, Susan Fairweather-Tait, Stefano Salvioli, Miriam Capri, Patrizia Brigidi, Claudio Franceschi, Cristina Fabbri, Claudia Bertarelli, Massimo IzziMario Mazzocchi, Jean Michel Chardigny, Beatrice Morio, Daniele Rossi, Maurizio Notarfonso, Paul W. O'Toole, Kevin Cashman, Simon R. Carding, Claudio Nicoletti, Dirk Jacobs, Maria Xipsiti, Laura Fernandez, Josephine Wills, Xavier Irz, Natalia Kuosmanen, Efstathios S. Gonos, Konstantinos Voutetakis, Michael Salmon, Olivier Toussaint, Bruce W. Traill, Giuseppe Nocella, Barbara Caracciolo, Weili Xu, Ikonen Mikko Ikonen, Tuula Tuure, Robert Brummer, Fawzi Kadi, Sylvie Breton, Marie Triomphe, Guido Magario, Filippo Villani, Annibale Pancrazio, Brigitte Teufner, Josef Stocker, Francisco Javier Echevarría, Jose Ramón Iglesias, František Smrž, Lucie Krejcirova, Efthimia Koytsomitropoulou, Konstantinos Georgakidis, Rezan Yornuk, Cihan Ucar, Ben Van Ommen, Jildau Bouwman, Sebastiano Collino, Clara Jankovics, Adrienn Losó, Willem de Vos, Susana Fuentes, Eric Commelin

Research output: Contribution to journalArticlepeer-review


The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalMechanisms of Ageing and Development
Publication statusPublished - 2014


  • Ageing
  • Elderly-tailored foods
  • Gut microbiota
  • Inflammaging
  • Mediterranean diet

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology
  • Medicine(all)


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