Colorectal cancer mortality trends in Córdoba, Argentina

Sonia Alejandra Pou, Alberto Rubén Osella, Aldo Renato Eynard, Camila Niclis, María del Pilar Diaz

Research output: Contribution to journalArticlepeer-review


Background: Colorectal cancer is a leading cause of death worldwide for men and women, and one of the most commonly diagnosed in Córdoba, Argentina. The aim of this work was to provide an up-to-date approach to descriptive epidemiology of colorectal cancer in Córdoba throughout the estimation of mortality trends in the period 1986-2006, using Joinpoint and age-period-cohort (APC) models. Methods: Age-standardized (world population) mortality rates (ASMR), overall and truncated (35-64 years), were calculated and Joinpoint regression performed to compute the estimated annual percentage changes (EAPC). Poisson sequential models were fitted to estimate the effect of age (11 age groups), period (1986-1990, 1991-1995, 1996-2000 or 2001-2006) and cohort (13 ten-years cohorts overlapping each other by five-years) on colorectal cancer mortality rates. Results: ASMR showed an overall significant decrease (EAPC -0.9 95%CI: -1.7, -0.2) for women, being more noticeable from 1996 onwards (EAPC -2.1 95%CI: -4.0, -0.1). Age-effect showed an important rise in both sexes, but more evident in males. Birth cohort- and period effects reflected increasing and decreasing tendencies for men and women, respectively. Conclusions: Differences in mortality rates were found according to sex and could be related to age-period-cohort effects linked to the ageing process, health care and lifestyle. Further research is needed to elucidate the specific age-, period- and cohort-related factors.

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalCancer Epidemiology
Issue number6
Publication statusPublished - Dec 2009


  • Age-period-cohort model
  • Argentina
  • Córdoba
  • Colorectal cancer
  • Mortality

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology


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