Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program

P. Odin; K. Ray Chaudhuri; J. T. Slevin; J. Volkmann; E. Dietrichs; P. Martinez-Martin; J. K. Krauss; T. Henriksen; R. Katzenschlager; A. Antonini; O. Rascol; W. Poewe; Thomas Brücke; Walter Pirker; Gerhard Ransmayr; Petra Schwingenschuh; Volker Tomantschger; Dieter Volc; Holger Jespersen; Akram Kamal; Merete Karlsborg; Lorenz Oppel; Stephen Pedersen; Sari Avikainen; Valtteri Kaasinen; Eero Pekkonen; Hanna Ruottinen; Jean Philippe Azulay; Jean Christophe Corvol; Christine Brefel Courbon; Luc Defebvre; Franck Durif; Jean Luc Houeto; Paul Krack; François Tison; Jürgen Andrich; Reinhard Ehret; Fabian Klostermann; Rejko Krüger; Paul Lingor; Robert Liszka; Johannes Schwarz; Lars Timmermann; Tobias Warnecke; Sevasti Bostantjopoulou; Spyridon Konitsiotis; Sokratis Papageorgiou; Pantelis Stathishens; Leonidas Stefanis; Panagiotis Zikos; Patrick Browne; Daniel Healy; Timothy Lynch; Sean O'Riordan; Sean O'Sullivan; Richard Walsh; Giovanni Abbruzzese; Leonardo Lopiano; Nicola Modugno; Filippo Tamma; Björn Holmberg; Jan Linder; Dag Nyholm; Sven Pålhagen; Jos Matías Arbelo; Rosa Yanez Bana; Juan Carlos Martinez Castrillo; Alfonso Castro; Pedro Jos e Garcia Ruiz Espiga; Jaime Kulisevsky; Elena Lezcano; Rosario Luquin; Pablo Mir; Victor Puente; Francesc Valldeoriola; David Burn; Carl Clarke; Thomas Foltynie; Donald Grosset; John Hindle; Alison Leake; Andrew Lees; Huw Morris; David Stewart; Richard Walker; Paul Worth

doi:10.1016/j.parkreldis.2015.07.020

Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program

P. Odin, K. Ray Chaudhuri, J. T. Slevin, J. Volkmann, E. Dietrichs, P. Martinez-Martin, J. K. Krauss, T. Henriksen, R. Katzenschlager, A. Antonini, O. Rascol, W. Poewe, Thomas Brücke, Walter Pirker, Gerhard Ransmayr, Petra Schwingenschuh, Volker Tomantschger, Dieter Volc, Holger Jespersen, Akram KamalMerete Karlsborg, Lorenz Oppel, Stephen Pedersen, Sari Avikainen, Valtteri Kaasinen, Eero Pekkonen, Hanna Ruottinen, Jean Philippe Azulay, Jean Christophe Corvol, Christine Brefel Courbon, Luc Defebvre, Franck Durif, Jean Luc Houeto, Paul Krack, François Tison, Jürgen Andrich, Reinhard Ehret, Fabian Klostermann, Rejko Krüger, Paul Lingor, Robert Liszka, Johannes Schwarz, Lars Timmermann, Tobias Warnecke, Sevasti Bostantjopoulou, Spyridon Konitsiotis, Sokratis Papageorgiou, Pantelis Stathishens, Leonidas Stefanis, Panagiotis Zikos, Patrick Browne, Daniel Healy, Timothy Lynch, Sean O'Riordan, Sean O'Sullivan, Richard Walsh, Giovanni Abbruzzese, Leonardo Lopiano, Nicola Modugno, Filippo Tamma, Björn Holmberg, Jan Linder, Dag Nyholm, Sven Pålhagen, Jos Matías Arbelo, Rosa Yanez Bana, Juan Carlos Martinez Castrillo, Alfonso Castro, Pedro Jos e Garcia Ruiz Espiga, Jaime Kulisevsky, Elena Lezcano, Rosario Luquin, Pablo Mir, Victor Puente, Francesc Valldeoriola, David Burn, Carl Clarke, Thomas Foltynie, Donald Grosset, John Hindle, Alison Leake, Andrew Lees, Huw Morris, David Stewart, Richard Walker, Paul Worth

Research output: Contribution to journal › Article › peer-review

Abstract

Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of 13 movement disorder specialists. The ISC identified 71 clinical questions important for device-aided management of PD. Fifty-six experts responded to a web-based survey, rating 15 questions as 'critically important;' these were refined to 10 questions by the ISC to be addressed through available evidence and expert opinion. Draft guidance was presented at international/national meetings and revised based on feedback. Key take-home points are:. • Patients requiring levodopa >5 times daily who have severe, troublesome 'off' periods (>1-2 h/day) despite optimal oral/transdermal levodopa or non-levodopa-based therapies should be referred for specialist assessment even if disease duration is 70 years who have mild or moderate cognitive impairment, severe depression or other contraindications to DBS.

Original language	English
Article number	2748
Pages (from-to)	1133-1144
Number of pages	12
Journal	Parkinsonism and Related Disorders
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/j.parkreldis.2015.07.020
Publication status	Published - Oct 1 2015

Keywords

Device-aided therapies
Dyskinesias
Motor fluctuations
Non-motor symptoms
Parkinson's disease

ASJC Scopus subject areas

Geriatrics and Gerontology
Clinical Neurology
Neurology

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Odin, P., Ray Chaudhuri, K., Slevin, J. T., Volkmann, J., Dietrichs, E., Martinez-Martin, P., Krauss, J. K., Henriksen, T., Katzenschlager, R., Antonini, A., Rascol, O., Poewe, W., Brücke, T., Pirker, W., Ransmayr, G., Schwingenschuh, P., Tomantschger, V., Volc, D., Jespersen, H., ... Worth, P. (2015). Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program. Parkinsonism and Related Disorders, 21(10), 1133-1144. [2748]. https://doi.org/10.1016/j.parkreldis.2015.07.020

Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease : Consensus from an international survey and discussion program. / Odin, P.; Ray Chaudhuri, K.; Slevin, J. T. et al.

In: Parkinsonism and Related Disorders, Vol. 21, No. 10, 2748, 01.10.2015, p. 1133-1144.

Research output: Contribution to journal › Article › peer-review

Odin, P, Ray Chaudhuri, K, Slevin, JT, Volkmann, J, Dietrichs, E, Martinez-Martin, P, Krauss, JK, Henriksen, T, Katzenschlager, R, Antonini, A, Rascol, O, Poewe, W, Brücke, T, Pirker, W, Ransmayr, G, Schwingenschuh, P, Tomantschger, V, Volc, D, Jespersen, H, Kamal, A, Karlsborg, M, Oppel, L, Pedersen, S, Avikainen, S, Kaasinen, V, Pekkonen, E, Ruottinen, H, Azulay, JP, Corvol, JC, Courbon, CB, Defebvre, L, Durif, F, Houeto, JL, Krack, P, Tison, F, Andrich, J, Ehret, R, Klostermann, F, Krüger, R, Lingor, P, Liszka, R, Schwarz, J, Timmermann, L, Warnecke, T, Bostantjopoulou, S, Konitsiotis, S, Papageorgiou, S, Stathishens, P, Stefanis, L, Zikos, P, Browne, P, Healy, D, Lynch, T, O'Riordan, S, O'Sullivan, S, Walsh, R, Abbruzzese, G, Lopiano, L, Modugno, N, Tamma, F, Holmberg, B, Linder, J, Nyholm, D, Pålhagen, S, Matías Arbelo, J, Bana, RY, Castrillo, JCM, Castro, A, e Garcia Ruiz Espiga, PJ, Kulisevsky, J, Lezcano, E, Luquin, R, Mir, P, Puente, V, Valldeoriola, F, Burn, D, Clarke, C, Foltynie, T, Grosset, D, Hindle, J, Leake, A, Lees, A, Morris, H, Stewart, D, Walker, R & Worth, P 2015, 'Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program', Parkinsonism and Related Disorders, vol. 21, no. 10, 2748, pp. 1133-1144. https://doi.org/10.1016/j.parkreldis.2015.07.020

Odin P, Ray Chaudhuri K, Slevin JT, Volkmann J, Dietrichs E, Martinez-Martin P et al. Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program. Parkinsonism and Related Disorders. 2015 Oct 1;21(10):1133-1144. 2748. doi: 10.1016/j.parkreldis.2015.07.020

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abstract = "Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of 13 movement disorder specialists. The ISC identified 71 clinical questions important for device-aided management of PD. Fifty-six experts responded to a web-based survey, rating 15 questions as 'critically important;' these were refined to 10 questions by the ISC to be addressed through available evidence and expert opinion. Draft guidance was presented at international/national meetings and revised based on feedback. Key take-home points are:. • Patients requiring levodopa >5 times daily who have severe, troublesome 'off' periods (>1-2 h/day) despite optimal oral/transdermal levodopa or non-levodopa-based therapies should be referred for specialist assessment even if disease duration is 70 years who have mild or moderate cognitive impairment, severe depression or other contraindications to DBS.",

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T2 - Consensus from an international survey and discussion program

AU - Odin, P.

AU - Ray Chaudhuri, K.

AU - Slevin, J. T.

AU - Volkmann, J.

AU - Dietrichs, E.

AU - Martinez-Martin, P.

AU - Krauss, J. K.

AU - Henriksen, T.

AU - Katzenschlager, R.

AU - Antonini, A.

AU - Rascol, O.

AU - Poewe, W.

AU - Brücke, Thomas

AU - Pirker, Walter

AU - Ransmayr, Gerhard

AU - Schwingenschuh, Petra

AU - Tomantschger, Volker

AU - Volc, Dieter

AU - Jespersen, Holger

AU - Kamal, Akram

AU - Karlsborg, Merete

AU - Oppel, Lorenz

AU - Pedersen, Stephen

AU - Avikainen, Sari

AU - Kaasinen, Valtteri

AU - Pekkonen, Eero

AU - Ruottinen, Hanna

AU - Azulay, Jean Philippe

AU - Corvol, Jean Christophe

AU - Courbon, Christine Brefel

AU - Defebvre, Luc

AU - Durif, Franck

AU - Houeto, Jean Luc

AU - Krack, Paul

AU - Tison, François

AU - Andrich, Jürgen

AU - Ehret, Reinhard

AU - Klostermann, Fabian

AU - Krüger, Rejko

AU - Lingor, Paul

AU - Liszka, Robert

AU - Schwarz, Johannes

AU - Timmermann, Lars

AU - Warnecke, Tobias

AU - Bostantjopoulou, Sevasti

AU - Konitsiotis, Spyridon

AU - Papageorgiou, Sokratis

AU - Stathishens, Pantelis

AU - Stefanis, Leonidas

AU - Zikos, Panagiotis

AU - Browne, Patrick

AU - Healy, Daniel

AU - Lynch, Timothy

AU - O'Riordan, Sean

AU - O'Sullivan, Sean

AU - Walsh, Richard

AU - Abbruzzese, Giovanni

AU - Lopiano, Leonardo

AU - Modugno, Nicola

AU - Tamma, Filippo

AU - Holmberg, Björn

AU - Linder, Jan

AU - Nyholm, Dag

AU - Pålhagen, Sven

AU - Matías Arbelo, Jos

AU - Bana, Rosa Yanez

AU - Castrillo, Juan Carlos Martinez

AU - Castro, Alfonso

AU - e Garcia Ruiz Espiga, Pedro Jos

AU - Kulisevsky, Jaime

AU - Lezcano, Elena

AU - Luquin, Rosario

AU - Mir, Pablo

AU - Puente, Victor

AU - Valldeoriola, Francesc

AU - Burn, David

AU - Clarke, Carl

AU - Foltynie, Thomas

AU - Grosset, Donald

AU - Hindle, John

AU - Leake, Alison

AU - Lees, Andrew

AU - Morris, Huw

AU - Stewart, David

AU - Walker, Richard

AU - Worth, Paul

PY - 2015/10/1

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AB - Navigate PD was an educational program established to supplement existing guidelines and provide recommendations on the management of Parkinson's disease (PD) refractory to oral/transdermal therapies. It involved 103 experts from 13 countries overseen by an International Steering Committee (ISC) of 13 movement disorder specialists. The ISC identified 71 clinical questions important for device-aided management of PD. Fifty-six experts responded to a web-based survey, rating 15 questions as 'critically important;' these were refined to 10 questions by the ISC to be addressed through available evidence and expert opinion. Draft guidance was presented at international/national meetings and revised based on feedback. Key take-home points are:. • Patients requiring levodopa >5 times daily who have severe, troublesome 'off' periods (>1-2 h/day) despite optimal oral/transdermal levodopa or non-levodopa-based therapies should be referred for specialist assessment even if disease duration is 70 years who have mild or moderate cognitive impairment, severe depression or other contraindications to DBS.

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KW - Motor fluctuations

KW - Non-motor symptoms

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Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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