TY - JOUR
T1 - Colistin resistance caused by inactivation of the MgrB regulator is not associated with decreased virulence of sequence type 258 KPC carbapenemase-producing Klebsiella pneumoniae
AU - Arena, Fabio
AU - De Angelis, Lucia Henrici
AU - Cannatelli, Antonio
AU - Di Pilato, Vincenzo
AU - Amorese, Marina
AU - D'andrea, Marco Maria
AU - Giani, Tommaso
AU - Rossolini, Gian Maria
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3]).
AB - Using a Galleria mellonella animal model, we compared the virulence of two sequence type 258 (ST258) KPC-producing Klebsiella pneumoniae strains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistant mgrB mutants. With both strains, the mgrB mutants did not exhibit modification in virulence. In the G. mellonella model, the clade 1 strain (capsular type cps-1 [wzi29, producing KPC-2]) was significantly more virulent than the clade 2 strain (capsular type cps-2 [wzi154, producing KPC-3]).
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U2 - 10.1128/AAC.02981-15
DO - 10.1128/AAC.02981-15
M3 - Article
AN - SCOPUS:84963770499
SN - 0066-4804
VL - 60
SP - 2509
EP - 2512
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -