Cognitive Stimulation Modulates Platelet Total Phospholipases A2 Activity in Subjects with Mild Cognitive Impairment

Marta Balietti; Cinzia Giuli; Patrizia Fattoretti; Paolo Fabbietti; Demetrio Postacchini; Fiorenzo Conti

doi:10.3233/JAD-150714

Cognitive Stimulation Modulates Platelet Total Phospholipases A₂ Activity in Subjects with Mild Cognitive Impairment

Marta Balietti, Cinzia Giuli, Patrizia Fattoretti, Paolo Fabbietti, Demetrio Postacchini, Fiorenzo Conti

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A₂ activity (tPLA₂A) in patients with mild cognitive impairment (MCI-P). At baseline, tPLA₂A negatively correlated with Mini-Mental State Examination score (MMSE-s): patients with MMSE-s 2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA₂A correlates with the cognitive conditions of MCI-P, and that CS acts selectively on subjects with a dysregulated tPLA₂A.

Original language	English
Pages (from-to)	957-962
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	50
Issue number	4
DOIs	https://doi.org/10.3233/JAD-150714
Publication status	Published - Feb 22 2016

Keywords

Blood platelets
cognitive stimulation
mild cognitive impairment
phospholipases A2

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology

Access to Document

10.3233/JAD-150714

Cite this

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abstract = "We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A2 activity (tPLA2A) in patients with mild cognitive impairment (MCI-P). At baseline, tPLA2A negatively correlated with Mini-Mental State Examination score (MMSE-s): patients with MMSE-s 2A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA2A correlates with the cognitive conditions of MCI-P, and that CS acts selectively on subjects with a dysregulated tPLA2A.",

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AU - Postacchini, Demetrio

AU - Conti, Fiorenzo

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