Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions

R. Battini; D. Chieffo; S. Bulgheroni; G. Piccini; C. Pecini; S. Lucibello; S. Lenzi; F. Moriconi; M. Pane; G. Astrea; G. Baranello; P. Alfieri; S. Vicari; D. Riva; G. Cioni; E. Mercuri

doi:10.1016/j.nmd.2017.11.018

Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions

R. Battini, D. Chieffo, S. Bulgheroni, G. Piccini, C. Pecini, S. Lucibello, S. Lenzi, F. Moriconi, M. Pane, G. Astrea, G. Baranello, P. Alfieri, S. Vicari, D. Riva, G. Cioni, E. Mercuri

IRCCS Fondazione Policlinico Universitario A. Gemelli

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of our prospective observational study was to assess profiles of cognitive function and a possible impairment of executive functions in a cohort of boys with Duchenne muscular dystrophy without intellectual and behavior disability. Forty Duchenne boys (range of age: 6 years to 11 years and 6 months) were assessed by Wechsler Intelligence scale and battery of tests including tasks assessing working memory and executive functions (inhibition and switching, problem solving and planning). In our cohort some aspects of cognitive function were often impaired. These included multitasking, problem solving, inhibition and working memory necessary to plan and direct goal oriented behavior. Our results support the suggestion that aspects of cognitive function could be impaired even in boys without intellectual disability and support the hypothesis that executive functions may play an important role in specific aspects of cognitive impairment in Duchenne muscular dystrophy. © 2017 Elsevier B.V.

Original language	English
Pages (from-to)	122-128
Number of pages	7
Journal	Neuromuscular Disorders
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.nmd.2017.11.018
Publication status	Published - 2018

Keywords

Article
behavior
behavior disorder
child
clinical article
cognition
cognitive defect
cohort analysis
controlled study
Duchenne muscular dystrophy
executive function
human
inhibition (psychology)
intellectual impairment
language
male
mental task
observational study
planning
priority journal
problem solving
prospective study
Wechsler intelligence scale for children
working memory

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10.1016/j.nmd.2017.11.018

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039773591&doi=10.1016%2fj.nmd.2017.11.018&partnerID=40&md5=6d983ce933fb118997031cf024b53248

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Battini, R., Chieffo, D., Bulgheroni, S., Piccini, G., Pecini, C., Lucibello, S., Lenzi, S., Moriconi, F., Pane, M., Astrea, G., Baranello, G., Alfieri, P., Vicari, S., Riva, D., Cioni, G., & Mercuri, E. (2018). Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions. Neuromuscular Disorders, 28(2), 122-128. https://doi.org/10.1016/j.nmd.2017.11.018

Battini, R, Chieffo, D, Bulgheroni, S, Piccini, G, Pecini, C, Lucibello, S, Lenzi, S, Moriconi, F, Pane, M, Astrea, G, Baranello, G, Alfieri, P, Vicari, S, Riva, D, Cioni, G & Mercuri, E 2018, 'Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions', Neuromuscular Disorders, vol. 28, no. 2, pp. 122-128. https://doi.org/10.1016/j.nmd.2017.11.018

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AU - Lenzi, S.

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AU - Pane, M.

AU - Astrea, G.

AU - Baranello, G.

AU - Alfieri, P.

AU - Vicari, S.

AU - Riva, D.

AU - Cioni, G.

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AB - The aim of our prospective observational study was to assess profiles of cognitive function and a possible impairment of executive functions in a cohort of boys with Duchenne muscular dystrophy without intellectual and behavior disability. Forty Duchenne boys (range of age: 6 years to 11 years and 6 months) were assessed by Wechsler Intelligence scale and battery of tests including tasks assessing working memory and executive functions (inhibition and switching, problem solving and planning). In our cohort some aspects of cognitive function were often impaired. These included multitasking, problem solving, inhibition and working memory necessary to plan and direct goal oriented behavior. Our results support the suggestion that aspects of cognitive function could be impaired even in boys without intellectual disability and support the hypothesis that executive functions may play an important role in specific aspects of cognitive impairment in Duchenne muscular dystrophy. © 2017 Elsevier B.V.

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Cognitive profile in Duchenne muscular dystrophy boys without intellectual disability: The role of executive functions

Abstract

Keywords

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