TY - JOUR
T1 - Cognitive and psychiatric characterization of patients with Huntington's disease and their at-risk relatives
AU - Soliveri, P.
AU - Monza, D.
AU - Piacentini, S.
AU - Paridi, D.
AU - Nespolo, C.
AU - Gellera, C.
AU - Mariotti, C.
AU - Albanese, A.
AU - Girotti, F.
PY - 2002/9
Y1 - 2002/9
N2 - We examined cognitive and psychiatric disturbances in patients with Huntington's disease (HD) in comparison to at risk asymptomatic subjects. Cognitive and psychiatric scales and an HD motor scale were administered to 40 HD patients, 17 pre-symptomatic HD gene carriers (AR+) and 28 non gene carriers (AR-). HD patients did worse than AR+ and AR- in all motor, cognitive and psychiatric measures, while AR+ and AR- subjects did not differ between each other. HD patients had high scores for negative psychiatric symptoms, but there was no correlation between illness duration and psychiatric or cognitive performance. In HD, disease course and symptomatology are heterogeneous and negative psychiatric symptoms are common.
AB - We examined cognitive and psychiatric disturbances in patients with Huntington's disease (HD) in comparison to at risk asymptomatic subjects. Cognitive and psychiatric scales and an HD motor scale were administered to 40 HD patients, 17 pre-symptomatic HD gene carriers (AR+) and 28 non gene carriers (AR-). HD patients did worse than AR+ and AR- in all motor, cognitive and psychiatric measures, while AR+ and AR- subjects did not differ between each other. HD patients had high scores for negative psychiatric symptoms, but there was no correlation between illness duration and psychiatric or cognitive performance. In HD, disease course and symptomatology are heterogeneous and negative psychiatric symptoms are common.
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U2 - 10.1007/s100720200091
DO - 10.1007/s100720200091
M3 - Article
C2 - 12548365
AN - SCOPUS:0036757010
SN - 1590-1874
VL - 23
JO - Neurological Sciences
JF - Neurological Sciences
IS - SUPPL. 2
ER -