Cocaine dependence and stroke: Pathogenesis and management

Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Antonia De Siena, Giovambattista De Sarro, Giovanni Malferrari, Marco Diana, Luca Gallelli

Research output: Contribution to journalArticlepeer-review


Cocaine abuse remains a devastating medical problem for our society. Current concepts suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result as a consequence of cocaine exposure. We provide an analysis of mechanisms of injury and a discussion of the pharmacological management of stroke following cocaine use. Preclinical research suggests that the cause of cocaine-mediated stroke is multifactorial and involves vasospasm, changes in cerebral vasculature, and platelet aggregation. We suggest that drugs able to induce vasospastic, thrombogenic, or neurotoxic effects of cocaine could be suitable as therapeutic agents. In contrast caution should be exerted when using anti-platelet and thrombolytic agents in cocaine users with stroke.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalCurrent Neurovascular Research
Issue number2
Publication statusPublished - 2015


  • Antineurotoxic agents
  • Antithrombogenic agents
  • Antivasospastic agents
  • Cocaine
  • Hemorrhagic stroke
  • Ischemic stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Medicine(all)


Dive into the research topics of 'Cocaine dependence and stroke: Pathogenesis and management'. Together they form a unique fingerprint.

Cite this