Clonal analysis of B-cell response in pemphigus course: Toward more effective therapies

Giovanni Di Zenzo; Giovanna Zambruno

doi:10.1038/jid.2014.499

Clonal analysis of B-cell response in pemphigus course: Toward more effective therapies

Research output: Contribution to journal › Article › peer-review

Abstract

In this issue, Hammers et al. report the first longitudinal study of B-cell responses in pemphigus vulgaris. They show persistence of the same sets of anti-desmoglein 3 (Dsg3) B-cell clones over time in two patients with active disease, suggesting that escape from tolerance is not a frequent event. In addition, the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab.

Original language	English
Pages (from-to)	651-654
Number of pages	4
Journal	Journal of Investigative Dermatology
Volume	135
Issue number	3
DOIs	https://doi.org/10.1038/jid.2014.499
Publication status	Published - Mar 12 2015

ASJC Scopus subject areas

Dermatology
Biochemistry
Cell Biology
Molecular Biology
Medicine(all)

Access to Document

10.1038/jid.2014.499

Cite this

@article{42f40c535e874aee914efeb6551c1a6e,

title = "Clonal analysis of B-cell response in pemphigus course: Toward more effective therapies",

abstract = "In this issue, Hammers et al. report the first longitudinal study of B-cell responses in pemphigus vulgaris. They show persistence of the same sets of anti-desmoglein 3 (Dsg3) B-cell clones over time in two patients with active disease, suggesting that escape from tolerance is not a frequent event. In addition, the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab.",

author = "{Di Zenzo}, Giovanni and Giovanna Zambruno",

year = "2015",

month = mar,

day = "12",

doi = "10.1038/jid.2014.499",

language = "English",

volume = "135",

pages = "651--654",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Clonal analysis of B-cell response in pemphigus course

T2 - Toward more effective therapies

AU - Di Zenzo, Giovanni

AU - Zambruno, Giovanna

PY - 2015/3/12

Y1 - 2015/3/12

N2 - In this issue, Hammers et al. report the first longitudinal study of B-cell responses in pemphigus vulgaris. They show persistence of the same sets of anti-desmoglein 3 (Dsg3) B-cell clones over time in two patients with active disease, suggesting that escape from tolerance is not a frequent event. In addition, the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab.

AB - In this issue, Hammers et al. report the first longitudinal study of B-cell responses in pemphigus vulgaris. They show persistence of the same sets of anti-desmoglein 3 (Dsg3) B-cell clones over time in two patients with active disease, suggesting that escape from tolerance is not a frequent event. In addition, the disappearance of anti-Dsg3 B-cell clones in two patients during long-term rituximab-induced remission supports the therapeutic potential of rituximab.

UR - http://www.scopus.com/inward/record.url?scp=84922570894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922570894&partnerID=8YFLogxK

U2 - 10.1038/jid.2014.499

DO - 10.1038/jid.2014.499

M3 - Article

C2 - 25666671

AN - SCOPUS:84922570894

SN - 0022-202X

VL - 135

SP - 651

EP - 654

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 3

ER -

Clonal analysis of B-cell response in pemphigus course: Toward more effective therapies

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this