G. Saviola, L. Abdi-Ali, M. R. Povino

Research output: Contribution to journalArticlepeer-review


Clodronate (CLO) is a bisphosphonate (BP) with proved efficacy in the treatment of osteoporosis. The reason of its activity is the anti-resorptive action, which is a common characteristic of BPs. Contrary to other BPs, CLO has a relatively low affinity for bone and a peculiar mechanism of action. CLO is effective in several diseases associated to excessive bone resorption as bone Paget’s disease and CRPS type I. Moreover, there are data showing activity of CLO in the erosive osteoarthritis of the hands, in the osteoarthritis of the knees, in the treatment of extra-articular calcifications and in preventing the mobilization of knee and hip prosthesis.

Original languageEnglish
Pages (from-to)719-722
Number of pages4
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number3
Publication statusPublished - Jul 1 2015

ASJC Scopus subject areas

  • Medicine(all)


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