Clinical response to tDCS depends on residual brain metabolism and grey matter integrity in patients with minimally conscious state

Aurore Thibaut; Carol Di Perri; Camille Chatelle; Marie Aurélie Bruno; Mohamed Ali Bahri; Sarah Wannez; Andrea Piarulli; Claire Bernard; Charlotte Martial; Lizette Heine; Roland Hustinx; Steven Laureys

doi:10.1016/j.brs.2015.07.024

Clinical response to tDCS depends on residual brain metabolism and grey matter integrity in patients with minimally conscious state

Aurore Thibaut, Carol Di Perri, Camille Chatelle, Marie Aurélie Bruno, Mohamed Ali Bahri, Sarah Wannez, Andrea Piarulli, Claire Bernard, Charlotte Martial, Lizette Heine, Roland Hustinx, Steven Laureys

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

Background Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. Objectives In this retrospective study, we investigated the relationship between tDCS responsiveness and neuroimaging data from MCS patients. Methods Structural Magnetic Resonance Imaging (MRI), Fluorodeoxyglucose Positron emission tomography (FDG-PET) and clinical electroencephalography (EEG) were acquired in 21 sub-acute and chronic MCS patients (8 tDCS responders) who subsequently (

Original language	English
Pages (from-to)	1116-1123
Number of pages	8
Journal	Brain Stimulation
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/j.brs.2015.07.024
Publication status	Published - Nov 1 2015

Keywords

Disorders of consciousness
Magnetic resonance imaging
Minimally conscious state
Positron emission tomography
Transcranial direct current stimulation
Treatment
Voxel-based morphometry

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)
Biophysics

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10.1016/j.brs.2015.07.024

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Thibaut, A., Di Perri, C., Chatelle, C., Bruno, M. A., Bahri, M. A., Wannez, S., Piarulli, A., Bernard, C., Martial, C., Heine, L., Hustinx, R., & Laureys, S. (2015). Clinical response to tDCS depends on residual brain metabolism and grey matter integrity in patients with minimally conscious state. Brain Stimulation, 8(6), 1116-1123. https://doi.org/10.1016/j.brs.2015.07.024

Thibaut, A, Di Perri, C, Chatelle, C, Bruno, MA, Bahri, MA, Wannez, S, Piarulli, A, Bernard, C, Martial, C, Heine, L, Hustinx, R & Laureys, S 2015, 'Clinical response to tDCS depends on residual brain metabolism and grey matter integrity in patients with minimally conscious state', Brain Stimulation, vol. 8, no. 6, pp. 1116-1123. https://doi.org/10.1016/j.brs.2015.07.024

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abstract = "Background Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. Objectives In this retrospective study, we investigated the relationship between tDCS responsiveness and neuroimaging data from MCS patients. Methods Structural Magnetic Resonance Imaging (MRI), Fluorodeoxyglucose Positron emission tomography (FDG-PET) and clinical electroencephalography (EEG) were acquired in 21 sub-acute and chronic MCS patients (8 tDCS responders) who subsequently (",

keywords = "Disorders of consciousness, Magnetic resonance imaging, Minimally conscious state, Positron emission tomography, Transcranial direct current stimulation, Treatment, Voxel-based morphometry",

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AU - Thibaut, Aurore

AU - Di Perri, Carol

AU - Chatelle, Camille

AU - Bruno, Marie Aurélie

AU - Bahri, Mohamed Ali

AU - Wannez, Sarah

AU - Piarulli, Andrea

AU - Bernard, Claire

AU - Martial, Charlotte

AU - Heine, Lizette

AU - Hustinx, Roland

AU - Laureys, Steven

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Background Transcranial direct current stimulation (tDCS) was recently shown to promote recovery of voluntary signs of consciousness in some patients in minimally conscious state (MCS). However, it remains unclear why clinical improvement is only observed in a subgroup of patients. Objectives In this retrospective study, we investigated the relationship between tDCS responsiveness and neuroimaging data from MCS patients. Methods Structural Magnetic Resonance Imaging (MRI), Fluorodeoxyglucose Positron emission tomography (FDG-PET) and clinical electroencephalography (EEG) were acquired in 21 sub-acute and chronic MCS patients (8 tDCS responders) who subsequently (

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KW - Magnetic resonance imaging

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KW - Positron emission tomography

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KW - Voxel-based morphometry

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Clinical response to tDCS depends on residual brain metabolism and grey matter integrity in patients with minimally conscious state

Abstract

Keywords

ASJC Scopus subject areas

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