Clinical presentation of hydatidiform mole in northern Italy: has it changed in the last 20 years?

Giorgia Mangili, Elisabetta Garavaglia, Paolo Cavoretto, Cinzia Gentile, Giovanna Scarfone, Emanuela Rabaiotti

Research output: Contribution to journalArticlepeer-review


Objective: This study was undertaken to evaluate whether the current clinical presentation of hydatidiform mole changed in the recent years compared with an historic group. Study Design: We retrieved 500 patients from our database. We compared the clinical presentation of 189 cases followed-up between 1992-2004 ("later" group) with that of a previous series of 311 patients ("earlier" group, 1970-1982). A Pearson χ2 test was performed analyzing the following variables: uterine volume, ovarian cysts, vaginal bleeding, hyperemesis, preeclampsia, and maternal age; we considered P <.05 to be significant. Results: Uterine volume corrected for gestational age (P <.0001), vaginal bleeding (P <.0001) and presence of ovarian cysts (P = .03) were significantly predominant in the "earlier" group, whereas the incidence of preeclampsia and hyperemesis were not significantly different. Conclusions: The depiction of increased uterine volume, ovarian theca lutein cysts, and vaginal bleeding in hydatidiform mole at presentation is significantly less frequent since the extensive dissemination of ultrasound in obstetrics.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Issue number3
Publication statusPublished - Mar 2008


  • gestational trophoblastic disease
  • hydatidiform mole
  • ultrasound

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology


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