Clinical pattern and associations of oxaliplatin acute neurotoxicity: A prospective study in 170 patients with colorectal cancer

Andreas A. Argyriou, Guido Cavaletti, Chiara Briani, Roser Velasco, Jordi Bruna, Marta Campagnolo, Paola Alberti, Francesca Bergamo, Diego Cortinovis, Marina Cazzaniga, Cristina Santos, Konstantinos Papadimitriou, Haralabos P. Kalofonos

Research output: Contribution to journalArticlepeer-review


Background: The objective of the current prospective, multicenter, international study was to trace the incidence and severity of acute oxaliplatin-induced peripheral neuropathy (OXLIPN) and to determine its clinical pattern. The authors also specifically tested whether patients who had more symptoms of acute OXLIPN eventually would develop a more severe chronic, cumulative form of OXLIPN. Methods: One hundred seventy patients (mean ± standard deviation age, 63.7 ± 8.7 years) who were scheduled to receive either combined leucovorin, 5-fluoruracil, and oxaliplatin (FOLFOX) or combined capecitabine and oxaliplatin (XELOX) for metastatic colorectal cancer were monitored prospectively at baseline and were followed in 4 European sites. The incidence of hyperexcitability symptoms secondary to acute OXLIPN was assessed by using a descriptive questionnaire (yes/no question) at each clinical evaluation. Motor and neurosensory criteria according to version 3 of the National Cancer Institute's Common Toxicity Criteria were applied to clinically grade the severity of OXLIPN. Results: Acute OXLIPN was present in 146 of 170 patients (85.9%). The vast majority of these patients manifested cold-induced perioral (95.2%) or pharyngolaryngeal (91.8%) dysesthesias. Severe acute OXLIPN that required prolongation of oxaliplatin infusion from 2 hours to 4 to 6 hours occurred in 32 of 146 patients (21.9%). The increased number of acute OXLIPN symptoms was correlated significantly (Spearman rho correlation coefficient [r]) with both the development (r = 0.602; P

Original languageEnglish
Pages (from-to)438-444
Number of pages7
Issue number2
Publication statusPublished - Jan 15 2013


  • acute neuropathy
  • hyperexcitability
  • neurotoxicity
  • oxaliplatin
  • peripheral nerve damage

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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