Clinical management of diffuse low-grade gliomas

Giuseppe Lombardi, Valeria Barresi, Antonella Castellano, Emeline Tabouret, Francesco Pasqualetti, Alessandro Salvalaggio, Giulia Cerretti, Mario Caccese, Marta Padovan, Vittorina Zagonel, Tamara Ius

Research output: Contribution to journalReview articlepeer-review


Diffuse low-grade gliomas (LGG) represent a heterogeneous group of primary brain tumors arising from supporting glial cells and usually affecting young adults. Advances in the knowledge of molecular profile of these tumors, including mutations in the isocitrate dehydrogenase genes, or 1p/19q codeletion, and in neuroradiological techniques have contributed to the diagnosis, prognostic stratification, and follow-up of these tumors. Optimal post-operative management of LGG is still controversial, though radiation therapy and chemotherapy remain the optimal treatments after surgical resection in selected patients. In this review, we report the most important and recent research on clinical and molecular features, new neuroradiological techniques, the different therapeutic modalities, and new opportunities for personalized targeted therapy and supportive care.

Original languageEnglish
Article number3008
Pages (from-to)1-25
Number of pages25
Issue number10
Publication statusPublished - Oct 16 2020


  • Chemotherapy
  • Diffuse low-grade gliomas
  • Radiotherapy
  • Surgery
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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