TY - JOUR
T1 - Clinical management of diffuse low-grade gliomas
AU - Lombardi, Giuseppe
AU - Barresi, Valeria
AU - Castellano, Antonella
AU - Tabouret, Emeline
AU - Pasqualetti, Francesco
AU - Salvalaggio, Alessandro
AU - Cerretti, Giulia
AU - Caccese, Mario
AU - Padovan, Marta
AU - Zagonel, Vittorina
AU - Ius, Tamara
N1 - Funding Information:
The authors thank Christina Drace for English support.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/16
Y1 - 2020/10/16
N2 - Diffuse low-grade gliomas (LGG) represent a heterogeneous group of primary brain tumors arising from supporting glial cells and usually affecting young adults. Advances in the knowledge of molecular profile of these tumors, including mutations in the isocitrate dehydrogenase genes, or 1p/19q codeletion, and in neuroradiological techniques have contributed to the diagnosis, prognostic stratification, and follow-up of these tumors. Optimal post-operative management of LGG is still controversial, though radiation therapy and chemotherapy remain the optimal treatments after surgical resection in selected patients. In this review, we report the most important and recent research on clinical and molecular features, new neuroradiological techniques, the different therapeutic modalities, and new opportunities for personalized targeted therapy and supportive care.
AB - Diffuse low-grade gliomas (LGG) represent a heterogeneous group of primary brain tumors arising from supporting glial cells and usually affecting young adults. Advances in the knowledge of molecular profile of these tumors, including mutations in the isocitrate dehydrogenase genes, or 1p/19q codeletion, and in neuroradiological techniques have contributed to the diagnosis, prognostic stratification, and follow-up of these tumors. Optimal post-operative management of LGG is still controversial, though radiation therapy and chemotherapy remain the optimal treatments after surgical resection in selected patients. In this review, we report the most important and recent research on clinical and molecular features, new neuroradiological techniques, the different therapeutic modalities, and new opportunities for personalized targeted therapy and supportive care.
KW - Chemotherapy
KW - Diffuse low-grade gliomas
KW - Radiotherapy
KW - Surgery
KW - Targeted therapy
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U2 - 10.3390/cancers12103008
DO - 10.3390/cancers12103008
M3 - Review article
AN - SCOPUS:85092597270
SN - 2072-6694
VL - 12
SP - 1
EP - 25
JO - Cancers
JF - Cancers
IS - 10
M1 - 3008
ER -