Clinical applications of hepatocyte transplantation

Giada Pietrosi, Giovanni Battista Vizzini, Salvatore Gruttadauria, Bruno Gridelli

Research output: Contribution to journalArticlepeer-review


The shortage of organ donors is a problem worldwide, with approximately 15% of adult patients with life-threatening liver diseases dying while on the waiting list. The use of cell transplantation for liver disease is an attempt to correct metabolic defects, or to support liver function as a bridge to liver transplantation and, as such, has raised a number of expectations. Most of the available studies briefly reported here focus on adult hepatocyte transplantation (HT), and the results are neither reproducible nor comparable, because the means of infusion, amount of injected cells and clinical variability differ among the studies. To better understand the specific role of HT in the management of end-stage liver disease, it is important that controlled studies, designed on the principles of evidence-based medicine, be done in order to guarantee the reproducibility of results.

Original languageEnglish
Pages (from-to)2074-2077
Number of pages4
JournalWorld Journal of Gastroenterology
Issue number17
Publication statusPublished - May 7 2009


  • Chronic liver disease
  • Hepatocyte transplantation
  • Liver failure
  • Metabolic diseases
  • Stem cells

ASJC Scopus subject areas

  • Gastroenterology


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