TY - CHAP
T1 - Circulating endothelial cells and circulating endothelial progenitors
AU - Mancuso, Patrizia
AU - Calleri, Angelica
AU - Bertolini, Francesco
PY - 2012
Y1 - 2012
N2 - The roles of circulating endothelial cells (CECs) and circulating endothelial progenitors (CEPs) are currently being investigated in several diseases including cancer and metastases development. Preclinical and clinical data suggest that CEC enumeration might be useful to identify patients who might benefit from anti-angiogenic treatments while CEPs seem to have a "catalytic" role in different steps of cancer progression and recurrence after therapy. The definition of CEC and CEP phenotypes and the standardization of CEC and CEP enumeration procedures are highly warranted to use these cells as biomarkers in clinical trials in oncology, and to compare results from different studies.
AB - The roles of circulating endothelial cells (CECs) and circulating endothelial progenitors (CEPs) are currently being investigated in several diseases including cancer and metastases development. Preclinical and clinical data suggest that CEC enumeration might be useful to identify patients who might benefit from anti-angiogenic treatments while CEPs seem to have a "catalytic" role in different steps of cancer progression and recurrence after therapy. The definition of CEC and CEP phenotypes and the standardization of CEC and CEP enumeration procedures are highly warranted to use these cells as biomarkers in clinical trials in oncology, and to compare results from different studies.
KW - Angiogenesis
KW - Endothelial cells
KW - Endothelial progenitors
UR - http://www.scopus.com/inward/record.url?scp=84860598148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860598148&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-28160-0_14
DO - 10.1007/978-3-642-28160-0_14
M3 - Chapter
C2 - 22527503
AN - SCOPUS:84860598148
SN - 9783642281594
VL - 195
T3 - Recent Results in Cancer Research
SP - 163
EP - 170
BT - Recent Results in Cancer Research
ER -