Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients

Maria Fusaro; Maurizio Gallieni; Andrea Aghi; Giorgio Iervasi; Maria A. Rizzo; Andrea Stucchi; Marianna Noale; Giovanni Tripepi; Thomas Nickolas; Nicola Veronese; Fabrizio Fabris; Sandro Giannini; Lorenzo Calò; Antonio Piccoli; Maria C. Mereu; Laura Cosmai; Alberto Ferraro; Fiorenza Magonara; Michela Spinello; Stefania Sella; Mario Plebani

doi:10.2174/1570161115666170919182421

Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients

Maria Fusaro, Maurizio Gallieni, Andrea Aghi, Giorgio Iervasi, Maria A. Rizzo, Andrea Stucchi, Marianna Noale, Giovanni Tripepi, Thomas Nickolas, Nicola Veronese, Fabrizio Fabris, Sandro Giannini, Lorenzo Calò, Antonio Piccoli, Maria C. Mereu, Laura Cosmai, Alberto Ferraro, Fiorenza Magonara, Michela Spinello, Stefania SellaMario Plebani

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.

Original language	English
Pages (from-to)	603-609
Number of pages	7
Journal	Current Vascular Pharmacology
Volume	16
Issue number	6
DOIs	https://doi.org/10.2174/1570161115666170919182421
Publication status	Published - Jan 1 2018

Keywords

BGP
Bone
Haemodialysis
Osteocalcin
Smoke
Vascular calcification
Vertebral fractures

ASJC Scopus subject areas

Pharmacology
Cardiology and Cardiovascular Medicine

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10.2174/1570161115666170919182421

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Fusaro, M., Gallieni, M., Aghi, A., Iervasi, G., Rizzo, M. A., Stucchi, A., Noale, M., Tripepi, G., Nickolas, T., Veronese, N., Fabris, F., Giannini, S., Calò, L., Piccoli, A., Mereu, M. C., Cosmai, L., Ferraro, A., Magonara, F., Spinello, M., ... Plebani, M. (2018). Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients. Current Vascular Pharmacology, 16(6), 603-609. https://doi.org/10.2174/1570161115666170919182421

Fusaro, M, Gallieni, M, Aghi, A, Iervasi, G, Rizzo, MA, Stucchi, A, Noale, M, Tripepi, G, Nickolas, T, Veronese, N, Fabris, F, Giannini, S, Calò, L, Piccoli, A, Mereu, MC, Cosmai, L, Ferraro, A, Magonara, F, Spinello, M, Sella, S & Plebani, M 2018, 'Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients', Current Vascular Pharmacology, vol. 16, no. 6, pp. 603-609. https://doi.org/10.2174/1570161115666170919182421

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title = "Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients",

abstract = "Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.",

keywords = "BGP, Bone, Haemodialysis, Osteocalcin, Smoke, Vascular calcification, Vertebral fractures",

author = "Maria Fusaro and Maurizio Gallieni and Andrea Aghi and Giorgio Iervasi and Rizzo, {Maria A.} and Andrea Stucchi and Marianna Noale and Giovanni Tripepi and Thomas Nickolas and Nicola Veronese and Fabrizio Fabris and Sandro Giannini and Lorenzo Cal{\`o} and Antonio Piccoli and Mereu, {Maria C.} and Laura Cosmai and Alberto Ferraro and Fiorenza Magonara and Michela Spinello and Stefania Sella and Mario Plebani",

year = "2018",

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doi = "10.2174/1570161115666170919182421",

language = "English",

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TY - JOUR

T1 - Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients

AU - Fusaro, Maria

AU - Gallieni, Maurizio

AU - Aghi, Andrea

AU - Iervasi, Giorgio

AU - Rizzo, Maria A.

AU - Stucchi, Andrea

AU - Noale, Marianna

AU - Tripepi, Giovanni

AU - Nickolas, Thomas

AU - Veronese, Nicola

AU - Fabris, Fabrizio

AU - Giannini, Sandro

AU - Calò, Lorenzo

AU - Piccoli, Antonio

AU - Mereu, Maria C.

AU - Cosmai, Laura

AU - Ferraro, Alberto

AU - Magonara, Fiorenza

AU - Spinello, Michela

AU - Sella, Stefania

AU - Plebani, Mario

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.

AB - Background: Bone Gamma-carboxyglutamic acid (Gla)-protein (BGP or osteocalcin) is a vitamin K-dependent protein involved in the regulation of bone mineralization. Smoking is a risk factor for osteoporosis. Methods: We carried out a secondary analysis of the Vitamin K Italian (VIKI) study to investigate the association between cigarette smoking and BGP levels in patients with end stage renal disease. Data were collected in 370 haemodialysis patients, 37% (136) smokers (or ex-smokers) and 63% (234) nonsmokers. Vascular calcifications and vertebral fractures (quantitative morphometry) were identified on spine radiographs. Results: Smokers had significantly lower BGP levels (152 vs. 204 μg/L, p=0.003). Smokers had lower plasma phosphate levels (4.2 vs. 4.7 mg/dl, p<0.01). Lower BGP levels were associated with aortic calcification (p<0.001), iliac calcification (p=0.042) and vertebral fractures (p=0.023). In addition, the regression model showed that smoking is associated with a significant reduction of total BGP levels by about 18% (p=0.01). Conclusion: This is the first clinical study in a haemodialysis population, which identifies cigarette smoking as a potential factor that can lower BGP levels, a protective agent in bone and vascular health.

KW - BGP

KW - Bone

KW - Haemodialysis

KW - Osteocalcin

KW - Smoke

KW - Vascular calcification

KW - Vertebral fractures

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SN - 1570-1611

VL - 16

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JO - Current Vascular Pharmacology

JF - Current Vascular Pharmacology

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ER -

Cigarette smoking is associated with decreased Bone Gla-Protein (BGP) levels in hemodialysis patients

Abstract

Keywords

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