Chronic viral hepatitis: The histology report

Maria Guido, Alessandra Mangia, Gavino Faa

Research output: Contribution to journalArticlepeer-review


In chronic viral hepatitis, the role of liver biopsy as a diagnostic test has seen a decline, paralleled by its increasing importance for prognostic purposes. Nowadays, the main indication for liver biopsy in chronic viral hepatitis is to assess the severity of the disease, in terms of both necro-inflammation (grade) and fibrosis (stage), which is important for prognosis and therapeutic management. Several scoring systems have been proposed for grading and staging chronic viral hepatitis and there is no a general consensus on the best system to be used in the daily practice. All scoring systems have their drawbacks and all may be affected by sampling and observer variability. Whatever the system used, a histological score is a reductive approach since damage in chronic viral hepatitis is a complex biological process. Thus, scoring systems are not intended to replace the detailed, descriptive, pathology report. In fact, lesions other than those scored for grading and staging may have clinical relevance and should be assessed and reported. This paper aims to provide a systematic approach to the interpretation of liver biopsies obtained in cases of chronic viral hepatitis, with the hope of helping general pathologists in their diagnostic practice.

Original languageEnglish
JournalDigestive and Liver Disease
Issue numberSUPPL. 4
Publication statusPublished - Mar 2011


  • Chronic viral hepatitis
  • GIPAD report
  • Liver biopsy
  • Scoring systems

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


Dive into the research topics of 'Chronic viral hepatitis: The histology report'. Together they form a unique fingerprint.

Cite this