Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution): proposal of a study protocol aimed to realize a validated risk score for early diagnosis

Cristiano Miotti; Andrea M D'Armini; Beatrice Scardovi; Stefano Ghio; Gianfranco Sinagra; Walter Serra; Antonella Romaniello; Giuseppe Galgano; Loris Roncon; Michele D'Alto; Daniela Giannazzo; Patrizio Vitulo; Amedeo Bongarzoni; Matteo Ruzzolini; Carlo Albera; Gavino Casu; Martina Perazzolo Marra; Sante D Pierdomenico; Federico Luongo; Giovanna Manzi; Silvia Papa; Gianmarco Scoccia; Nadia Cedrone; Roberto Badagliacca; Carmine D Vizza

doi:10.23736/S2724-5683.21.05575-7

Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution): proposal of a study protocol aimed to realize a validated risk score for early diagnosis

Cristiano Miotti, Andrea M D'Armini, Beatrice Scardovi, Stefano Ghio, Gianfranco Sinagra, Walter Serra, Antonella Romaniello, Giuseppe Galgano, Loris Roncon, Michele D'Alto, Daniela Giannazzo, Patrizio Vitulo, Amedeo Bongarzoni, Matteo Ruzzolini, Carlo Albera, Gavino Casu, Martina Perazzolo Marra, Sante D Pierdomenico, Federico Luongo, Giovanna ManziSilvia Papa, Gianmarco Scoccia, Nadia Cedrone, Roberto Badagliacca, Carmine D Vizza

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is the most serious long-term complication of acute pulmonary embolism (PE) though it is the only potentially reversible form of Pulmonary Hypertension (PH). Its incidence is mainly limited to the first 2 years following the embolic event, however it is often underdiagnosed or misdiagnosed.

METHODS: This is a multicenter observational cross-sectional and prospective study. Patients with a prior diagnosis of PE will be enrolled and undergo baseline evaluation for prevalent PH detection through a clinical examination and an echocardiogram as first screening exam. All cases of intermediate-high echocardiographic probability of PH will be confirmed by right heart catheterization and then identified as CTEPH through appropriate imaging and functional examinations in order to exclude other causes of PH. A CTEPH Risk Score will be created using retrospective data from this prevalent cohort of patients and will be then validated on an incident cohort of patients with acute PE.

RESULTS: 1000 retrospective and 218 prospective patients are expected to be enrolled and the study is expected to be completed by the end of 2021. Up to now 841 patients (620 retrospective and 221 prospective) have been enrolled.

CONCLUSIONS: This study is the first large prospective study for the prediction of CTEPH development in patients with PE. It aims to create a comprehensive scoring tool that includes echocardiographic data which may allow early detection of CTEPH and the application of targeted follow up screening programs in patients with PE.

Original language	English
Journal	Minerva Cardiology and Angiology
DOIs	https://doi.org/10.23736/S2724-5683.21.05575-7
Publication status	E-pub ahead of print - Mar 11 2021

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10.23736/S2724-5683.21.05575-7

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Miotti, C., D'Armini, A. M., Scardovi, B., Ghio, S., Sinagra, G., Serra, W., Romaniello, A., Galgano, G., Roncon, L., D'Alto, M., Giannazzo, D., Vitulo, P., Bongarzoni, A., Ruzzolini, M., Albera, C., Casu, G., Perazzolo Marra, M., Pierdomenico, S. D., Luongo, F., ... Vizza, C. D. (2021). Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution): proposal of a study protocol aimed to realize a validated risk score for early diagnosis. Minerva Cardiology and Angiology. https://doi.org/10.23736/S2724-5683.21.05575-7

Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution) : proposal of a study protocol aimed to realize a validated risk score for early diagnosis. / Miotti, Cristiano; D'Armini, Andrea M; Scardovi, Beatrice et al.

In: Minerva Cardiology and Angiology, 11.03.2021.

Research output: Contribution to journal › Article › peer-review

Miotti, C, D'Armini, AM, Scardovi, B, Ghio, S, Sinagra, G, Serra, W, Romaniello, A, Galgano, G, Roncon, L, D'Alto, M, Giannazzo, D, Vitulo, P, Bongarzoni, A, Ruzzolini, M, Albera, C, Casu, G, Perazzolo Marra, M, Pierdomenico, SD, Luongo, F, Manzi, G, Papa, S, Scoccia, G, Cedrone, N, Badagliacca, R & Vizza, CD 2021, 'Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution): proposal of a study protocol aimed to realize a validated risk score for early diagnosis', Minerva Cardiology and Angiology. https://doi.org/10.23736/S2724-5683.21.05575-7

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title = "Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution): proposal of a study protocol aimed to realize a validated risk score for early diagnosis",

abstract = "BACKGROUND: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is the most serious long-term complication of acute pulmonary embolism (PE) though it is the only potentially reversible form of Pulmonary Hypertension (PH). Its incidence is mainly limited to the first 2 years following the embolic event, however it is often underdiagnosed or misdiagnosed.METHODS: This is a multicenter observational cross-sectional and prospective study. Patients with a prior diagnosis of PE will be enrolled and undergo baseline evaluation for prevalent PH detection through a clinical examination and an echocardiogram as first screening exam. All cases of intermediate-high echocardiographic probability of PH will be confirmed by right heart catheterization and then identified as CTEPH through appropriate imaging and functional examinations in order to exclude other causes of PH. A CTEPH Risk Score will be created using retrospective data from this prevalent cohort of patients and will be then validated on an incident cohort of patients with acute PE.RESULTS: 1000 retrospective and 218 prospective patients are expected to be enrolled and the study is expected to be completed by the end of 2021. Up to now 841 patients (620 retrospective and 221 prospective) have been enrolled.CONCLUSIONS: This study is the first large prospective study for the prediction of CTEPH development in patients with PE. It aims to create a comprehensive scoring tool that includes echocardiographic data which may allow early detection of CTEPH and the application of targeted follow up screening programs in patients with PE.",

author = "Cristiano Miotti and D'Armini, {Andrea M} and Beatrice Scardovi and Stefano Ghio and Gianfranco Sinagra and Walter Serra and Antonella Romaniello and Giuseppe Galgano and Loris Roncon and Michele D'Alto and Daniela Giannazzo and Patrizio Vitulo and Amedeo Bongarzoni and Matteo Ruzzolini and Carlo Albera and Gavino Casu and {Perazzolo Marra}, Martina and Pierdomenico, {Sante D} and Federico Luongo and Giovanna Manzi and Silvia Papa and Gianmarco Scoccia and Nadia Cedrone and Roberto Badagliacca and Vizza, {Carmine D}",

year = "2021",

month = mar,

day = "11",

doi = "10.23736/S2724-5683.21.05575-7",

language = "English",

journal = "Minerva Cardiology and Angiology",

issn = "2724-5772",

publisher = "Edizioni Minerva Medica S.p.A.",

}

TY - JOUR

T1 - Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution)

T2 - proposal of a study protocol aimed to realize a validated risk score for early diagnosis

AU - Miotti, Cristiano

AU - D'Armini, Andrea M

AU - Scardovi, Beatrice

AU - Ghio, Stefano

AU - Sinagra, Gianfranco

AU - Serra, Walter

AU - Romaniello, Antonella

AU - Galgano, Giuseppe

AU - Roncon, Loris

AU - D'Alto, Michele

AU - Giannazzo, Daniela

AU - Vitulo, Patrizio

AU - Bongarzoni, Amedeo

AU - Ruzzolini, Matteo

AU - Albera, Carlo

AU - Casu, Gavino

AU - Perazzolo Marra, Martina

AU - Pierdomenico, Sante D

AU - Luongo, Federico

AU - Manzi, Giovanna

AU - Papa, Silvia

AU - Scoccia, Gianmarco

AU - Cedrone, Nadia

AU - Badagliacca, Roberto

AU - Vizza, Carmine D

PY - 2021/3/11

Y1 - 2021/3/11

N2 - BACKGROUND: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is the most serious long-term complication of acute pulmonary embolism (PE) though it is the only potentially reversible form of Pulmonary Hypertension (PH). Its incidence is mainly limited to the first 2 years following the embolic event, however it is often underdiagnosed or misdiagnosed.METHODS: This is a multicenter observational cross-sectional and prospective study. Patients with a prior diagnosis of PE will be enrolled and undergo baseline evaluation for prevalent PH detection through a clinical examination and an echocardiogram as first screening exam. All cases of intermediate-high echocardiographic probability of PH will be confirmed by right heart catheterization and then identified as CTEPH through appropriate imaging and functional examinations in order to exclude other causes of PH. A CTEPH Risk Score will be created using retrospective data from this prevalent cohort of patients and will be then validated on an incident cohort of patients with acute PE.RESULTS: 1000 retrospective and 218 prospective patients are expected to be enrolled and the study is expected to be completed by the end of 2021. Up to now 841 patients (620 retrospective and 221 prospective) have been enrolled.CONCLUSIONS: This study is the first large prospective study for the prediction of CTEPH development in patients with PE. It aims to create a comprehensive scoring tool that includes echocardiographic data which may allow early detection of CTEPH and the application of targeted follow up screening programs in patients with PE.

AB - BACKGROUND: Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is the most serious long-term complication of acute pulmonary embolism (PE) though it is the only potentially reversible form of Pulmonary Hypertension (PH). Its incidence is mainly limited to the first 2 years following the embolic event, however it is often underdiagnosed or misdiagnosed.METHODS: This is a multicenter observational cross-sectional and prospective study. Patients with a prior diagnosis of PE will be enrolled and undergo baseline evaluation for prevalent PH detection through a clinical examination and an echocardiogram as first screening exam. All cases of intermediate-high echocardiographic probability of PH will be confirmed by right heart catheterization and then identified as CTEPH through appropriate imaging and functional examinations in order to exclude other causes of PH. A CTEPH Risk Score will be created using retrospective data from this prevalent cohort of patients and will be then validated on an incident cohort of patients with acute PE.RESULTS: 1000 retrospective and 218 prospective patients are expected to be enrolled and the study is expected to be completed by the end of 2021. Up to now 841 patients (620 retrospective and 221 prospective) have been enrolled.CONCLUSIONS: This study is the first large prospective study for the prediction of CTEPH development in patients with PE. It aims to create a comprehensive scoring tool that includes echocardiographic data which may allow early detection of CTEPH and the application of targeted follow up screening programs in patients with PE.

U2 - 10.23736/S2724-5683.21.05575-7

DO - 10.23736/S2724-5683.21.05575-7

M3 - Article

C2 - 33703863

SN - 2724-5772

JO - Minerva Cardiology and Angiology

JF - Minerva Cardiology and Angiology

ER -

Chronic thromboembolic pulmonary hypertension risk score evaluation and validation (CTEPH Solution): proposal of a study protocol aimed to realize a validated risk score for early diagnosis

Abstract

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