Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma

Simona Coco; Francesca Valdora; Stefano Bonassi; Paola Scaruffi; Sara Stigliani; André Oberthuer; Frank Berthold; Immacolata Andolfo; Tiziana Servidei; Riccardo Riccardi; Eleonora Basso; Achille Iolascon; Gian Paolo Tonini

doi:10.1089/omi.2010.0103

Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma

Simona Coco, Francesca Valdora, Stefano Bonassi, Paola Scaruffi, Sara Stigliani, André Oberthuer, Frank Berthold, Immacolata Andolfo, Tiziana Servidei, Riccardo Riccardi, Eleonora Basso, Achille Iolascon, Gian Paolo Tonini

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Abstract

Medulloblastoma (MB) is one of the most aggressive pediatric brain tumor. We report genome-wide pooled-analysis of classic MB variant of patients over 3 years of age at diagnosis. We combined array comparative genomic hybridization (aCGH) results from experimental analysis (31 cases) with two public databases (55 cases) in a final evaluation of 86 MBs. The most common chromosome structural aberrations were gains of 17q (45.3%), 1q (22.1%), and losses of 8p (15.1%), 10q (19.8%), 17p (37.2%), and 16q (16.3%). Isochromome (17q) was observed in 29.1% MBs. A significant association between poor patients survival and losses of 9q (p

Original language	English
Pages (from-to)	273-280
Number of pages	8
Journal	OMICS A Journal of Integrative Biology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1089/omi.2010.0103
Publication status	Published - May 1 2011

ASJC Scopus subject areas

Biotechnology
Biochemistry
Genetics
Molecular Biology
Molecular Medicine

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Coco, S., Valdora, F., Bonassi, S., Scaruffi, P., Stigliani, S., Oberthuer, A., Berthold, F., Andolfo, I., Servidei, T., Riccardi, R., Basso, E., Iolascon, A., & Tonini, G. P. (2011). Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma. OMICS A Journal of Integrative Biology, 15(5), 273-280. https://doi.org/10.1089/omi.2010.0103

Coco, S, Valdora, F, Bonassi, S, Scaruffi, P, Stigliani, S, Oberthuer, A, Berthold, F, Andolfo, I, Servidei, T, Riccardi, R, Basso, E, Iolascon, A & Tonini, GP 2011, 'Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma', OMICS A Journal of Integrative Biology, vol. 15, no. 5, pp. 273-280. https://doi.org/10.1089/omi.2010.0103

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title = "Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma",

abstract = "Medulloblastoma (MB) is one of the most aggressive pediatric brain tumor. We report genome-wide pooled-analysis of classic MB variant of patients over 3 years of age at diagnosis. We combined array comparative genomic hybridization (aCGH) results from experimental analysis (31 cases) with two public databases (55 cases) in a final evaluation of 86 MBs. The most common chromosome structural aberrations were gains of 17q (45.3%), 1q (22.1%), and losses of 8p (15.1%), 10q (19.8%), 17p (37.2%), and 16q (16.3%). Isochromome (17q) was observed in 29.1% MBs. A significant association between poor patients survival and losses of 9q (p",

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AU - Valdora, Francesca

AU - Bonassi, Stefano

AU - Scaruffi, Paola

AU - Stigliani, Sara

AU - Oberthuer, André

AU - Berthold, Frank

AU - Andolfo, Immacolata

AU - Servidei, Tiziana

AU - Riccardi, Riccardo

AU - Basso, Eleonora

AU - Iolascon, Achille

AU - Tonini, Gian Paolo

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Chromosome 9q and 16q loss identified by genome-wide pooled-analysis are associated with tumor aggressiveness in patients with classic medulloblastoma

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