TY - JOUR
T1 - Chromatin structure, DNA methylation, and gene expression at sites of viral integration in human fibroblasts. Implications for chromosomal fragility
AU - De Ambrosis, Alessandro
AU - Casciano, Ida
AU - Querzola, Flavia
AU - Vidali, Giorgio
AU - Romani, Massimo
PY - 1992
Y1 - 1992
N2 - We analyzed the structural and functional properties of a chromosomal region in which a recombinant hybrid virus adenovirus 5/SV40 preferentially integrates. Our results demonstrated that the structure of the cellular targets for DNA and RNA viruses is very similar and that the cellular sequence flanking the integrated virus possesses, simultaneously, all the features postulated to be the molecular basis for chromosomal fragility.
AB - We analyzed the structural and functional properties of a chromosomal region in which a recombinant hybrid virus adenovirus 5/SV40 preferentially integrates. Our results demonstrated that the structure of the cellular targets for DNA and RNA viruses is very similar and that the cellular sequence flanking the integrated virus possesses, simultaneously, all the features postulated to be the molecular basis for chromosomal fragility.
UR - http://www.scopus.com/inward/record.url?scp=0026663877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026663877&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(92)90223-U
DO - 10.1016/0165-4608(92)90223-U
M3 - Article
C2 - 1317251
AN - SCOPUS:0026663877
SN - 0165-4608
VL - 60
SP - 1
EP - 7
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -