TY - JOUR
T1 - Cholinesterase inhibitor use in Alzheimer's disease
T2 - The EPIFARM-Elderly Project
AU - Franchi, Carlotta
AU - Lucca, Ugo
AU - Tettamanti, Mauro
AU - Riva, Emma
AU - Fortino, Ida
AU - Bortolotti, Angela
AU - Merlino, Luca
AU - Pasina, Luca
AU - Nobili, Alessandro
PY - 2011/5
Y1 - 2011/5
N2 - Purpose: This study was designed to examine the prevalence of cholinesterase inhibitor (ChEI) use and the proportions of patients treated with ChEIs by using an administrative prescription database of prevalent and incident cases of mild to moderate Alzheimer's disease (AD) in relation to age and duration of therapy. Methods: A prospective observational study covering individuals aged 65years or older who received at least one prescription of ChEIs between 1 January 2002 and 31 December 2007 was conducted in three health administrative areas in the Lombardy Region, Italy. Results: The prevalence of those who received at least one prescription for ChEIs rose from 0.5% in 2002 to 0.7% in 2004, reaching a plateau. Among estimated prevalent cases of mild to moderate AD, the prevalence of patients who received at least one prescription of ChEIs varied in different age groups, rising in those over 80years and falling slightly in those under 80years, particularly in patients aged 65-69years (test for trend, p
AB - Purpose: This study was designed to examine the prevalence of cholinesterase inhibitor (ChEI) use and the proportions of patients treated with ChEIs by using an administrative prescription database of prevalent and incident cases of mild to moderate Alzheimer's disease (AD) in relation to age and duration of therapy. Methods: A prospective observational study covering individuals aged 65years or older who received at least one prescription of ChEIs between 1 January 2002 and 31 December 2007 was conducted in three health administrative areas in the Lombardy Region, Italy. Results: The prevalence of those who received at least one prescription for ChEIs rose from 0.5% in 2002 to 0.7% in 2004, reaching a plateau. Among estimated prevalent cases of mild to moderate AD, the prevalence of patients who received at least one prescription of ChEIs varied in different age groups, rising in those over 80years and falling slightly in those under 80years, particularly in patients aged 65-69years (test for trend, p
KW - Alzheimer's disease
KW - Cholinesterase inhibitors
KW - Drug utilization study
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U2 - 10.1002/pds.2124
DO - 10.1002/pds.2124
M3 - Article
C2 - 21432941
AN - SCOPUS:79955132362
SN - 1053-8569
VL - 20
SP - 497
EP - 505
JO - Pharmacoepidemiology and Drug Safety
JF - Pharmacoepidemiology and Drug Safety
IS - 5
ER -