Cholesterol synthesis in rat brain: Differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14

R. Fumagalli; E. Grossi; M. Poggi; P. Paoletti; S. Garattini

Cholesterol synthesis in rat brain: Differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14

R. Fumagalli, E. Grossi, M. Poggi, P. Paoletti, S. Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The incorporation of mevalonolactone and potassium mevalonate into lipid fractions of liver and brain has been evaluated. Brain slices have been shown to incorporate potassium mevalonate to a greater extent than mevalonolactone into unsaponifiable and digitonin-precipitable material. In brain homogenates similar data have been obtained. In liver this effect has not been observed. Results are discussed.

Original language	English
Pages (from-to)	529-533
Number of pages	5
Journal	Archives of Biochemistry and Biophysics
Volume	99
Issue number	3
Publication status	Published - Dec 1962

ASJC Scopus subject areas

Molecular Biology
Biophysics
Biochemistry

Cite this

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abstract = "The incorporation of mevalonolactone and potassium mevalonate into lipid fractions of liver and brain has been evaluated. Brain slices have been shown to incorporate potassium mevalonate to a greater extent than mevalonolactone into unsaponifiable and digitonin-precipitable material. In brain homogenates similar data have been obtained. In liver this effect has not been observed. Results are discussed.",

author = "R. Fumagalli and E. Grossi and M. Poggi and P. Paoletti and S. Garattini",

year = "1962",

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AU - Grossi, E.

AU - Poggi, M.

AU - Paoletti, P.

AU - Garattini, S.

PY - 1962/12

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N2 - The incorporation of mevalonolactone and potassium mevalonate into lipid fractions of liver and brain has been evaluated. Brain slices have been shown to incorporate potassium mevalonate to a greater extent than mevalonolactone into unsaponifiable and digitonin-precipitable material. In brain homogenates similar data have been obtained. In liver this effect has not been observed. Results are discussed.

AB - The incorporation of mevalonolactone and potassium mevalonate into lipid fractions of liver and brain has been evaluated. Brain slices have been shown to incorporate potassium mevalonate to a greater extent than mevalonolactone into unsaponifiable and digitonin-precipitable material. In brain homogenates similar data have been obtained. In liver this effect has not been observed. Results are discussed.

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Cholesterol synthesis in rat brain: Differential incorporation of mevalonolactone-2-C14 and potassium mevalonate-2-C14

Abstract

ASJC Scopus subject areas

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