TY - JOUR
T1 - Chemotherapy-related toxicity in patients with non-metastatic Ewing sarcoma
T2 - Influence of sex and age
AU - Paioli, Anna
AU - Luksch, Roberto
AU - Fagioli, Franca
AU - Tamburini, Angela
AU - Cesari, Marilena
AU - Palmerini, Emanuela
AU - Abate, Massimo Eraldo
AU - Marchesi, Emanuela
AU - Balladelli, Alba
AU - Pratelli, Loredana
AU - Ferrari, Stefano
PY - 2014
Y1 - 2014
N2 - Influence of age and sex on chemotherapy-related toxicity was evaluated in children (3-9 years), adolescents (10-17 years), and adults (up to 40 years) with localized Ewing sarcoma (ES) enrolled in the ISG/SSG III protocol. Treatment was based on vincristine, doxorubicin, cyclophosphamide, ifosfamide, dactinomycin, and etoposide. High-dose chemotherapy with busulfan and melphalan was given in poor responder patients. The analysis was based on 2191 courses of standard chemotherapy and 230 patients. A lower risk of G4 leukopenia and thrombocytopenia, hospitalization, febrile neutropenia, and red blood cell (RBC) transfusions was observed in males. Use of granulocyte colony-stimulating factor (G-CSF) was more frequent in adults, while children more often received RBC transfusions. A significant correlation between sex and chemotherapy-related toxicity was observed in the study, whereas no significant differences in terms of bone marrow toxicity can be expected according to patient age. Further studies should analyse the role of pharmacokinetics, pharmacogenomics, and clinical characteristics.
AB - Influence of age and sex on chemotherapy-related toxicity was evaluated in children (3-9 years), adolescents (10-17 years), and adults (up to 40 years) with localized Ewing sarcoma (ES) enrolled in the ISG/SSG III protocol. Treatment was based on vincristine, doxorubicin, cyclophosphamide, ifosfamide, dactinomycin, and etoposide. High-dose chemotherapy with busulfan and melphalan was given in poor responder patients. The analysis was based on 2191 courses of standard chemotherapy and 230 patients. A lower risk of G4 leukopenia and thrombocytopenia, hospitalization, febrile neutropenia, and red blood cell (RBC) transfusions was observed in males. Use of granulocyte colony-stimulating factor (G-CSF) was more frequent in adults, while children more often received RBC transfusions. A significant correlation between sex and chemotherapy-related toxicity was observed in the study, whereas no significant differences in terms of bone marrow toxicity can be expected according to patient age. Further studies should analyse the role of pharmacokinetics, pharmacogenomics, and clinical characteristics.
KW - Age
KW - Chemotherapy
KW - Ewing sarcoma
KW - Sex
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=84893061274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893061274&partnerID=8YFLogxK
U2 - 10.1179/1973947813Y.0000000103
DO - 10.1179/1973947813Y.0000000103
M3 - Article
C2 - 24091100
AN - SCOPUS:84893061274
SN - 1120-009X
VL - 26
SP - 49
EP - 56
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
IS - 1
ER -