Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Alberto Mantovani; Paola Allavena; Silvano Sozzani; Annunciata Vecchi; Massimo Locati; Antonio Sica

doi:10.1016/j.semcancer.2003.10.001

Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Alberto Mantovani, Paola Allavena, Silvano Sozzani, Annunciata Vecchi, Massimo Locati, Antonio Sica

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

Original language	English
Pages (from-to)	155-160
Number of pages	6
Journal	Seminars in Cancer Biology
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/j.semcancer.2003.10.001
Publication status	Published - Jun 2004

Keywords

Chemokines
Infiltrating leukocytes
Recruitment

ASJC Scopus subject areas

Cancer Research

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10.1016/j.semcancer.2003.10.001

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title = "Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors",

abstract = "Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.",

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author = "Alberto Mantovani and Paola Allavena and Silvano Sozzani and Annunciata Vecchi and Massimo Locati and Antonio Sica",

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AU - Mantovani, Alberto

AU - Allavena, Paola

AU - Sozzani, Silvano

AU - Vecchi, Annunciata

AU - Locati, Massimo

AU - Sica, Antonio

PY - 2004/6

Y1 - 2004/6

N2 - Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

AB - Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.

KW - Chemokines

KW - Infiltrating leukocytes

KW - Recruitment

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Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors

Abstract

Keywords

ASJC Scopus subject areas

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