Leukocytes, and macrophages in particular, are an important component of the stroma of neoplastic tissues. Tumor-associated macrophages (TAM) have the properties of a polarized M2 population and are a key component of inflammatory circuits which promote tumor growth and progression. Chemokines play a key role in the recruitment and positioning of TAM and dendritic cells in tumors and contribute to shaping their functional properties. Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression.
|Number of pages||6|
|Journal||Seminars in Cancer Biology|
|Publication status||Published - Jun 2004|
- Infiltrating leukocytes
ASJC Scopus subject areas
- Cancer Research