Chemokines as relay signals in human dendritic cell migration: Serum amyloid A kicks off chemotaxis

Silvano Sozzani; Annalisa Del Prete

doi:10.1002/eji.201445305

Chemokines as relay signals in human dendritic cell migration: Serum amyloid A kicks off chemotaxis

Silvano Sozzani, Annalisa Del Prete

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Cell migration is a response highly conserved in evolution. Chemotactic factors secreted in injured and inflamed tissues generate a concentration-based, chemotactic gradient that directs leukocytes from the blood compartment into tissue. In this issue of the European Journal of Immunology, Gouwy et al. [Eur. J. Immunol. 2015. 45: 101-112] show that the SAA1α isoform of serum amyloid A (SAA), which is an acute phase protein upregulated in inflammation and shown to chemoattract some leukocyte subsets, is also able to chemoattract monocyte-derived immature dendritic cells (DCs). The authors also show that the chemotactic activity of SAA1α for monocytes and DCs is indirectly mediated by rapid chemokine induction, providing evidence that proposes a new level of regulation of leukocyte migration.

Original language	English
Pages (from-to)	40-43
Number of pages	4
Journal	European Journal of Immunology
Volume	45
Issue number	1
DOIs	https://doi.org/10.1002/eji.201445305
Publication status	Published - Jan 1 2015

Keywords

Chemokines
Chemotaxis
Dendritic cells
Migration
Monocytes
Serum amyloid A

ASJC Scopus subject areas

Immunology
Immunology and Allergy
Medicine(all)

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10.1002/eji.201445305

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abstract = "Cell migration is a response highly conserved in evolution. Chemotactic factors secreted in injured and inflamed tissues generate a concentration-based, chemotactic gradient that directs leukocytes from the blood compartment into tissue. In this issue of the European Journal of Immunology, Gouwy et al. [Eur. J. Immunol. 2015. 45: 101-112] show that the SAA1α isoform of serum amyloid A (SAA), which is an acute phase protein upregulated in inflammation and shown to chemoattract some leukocyte subsets, is also able to chemoattract monocyte-derived immature dendritic cells (DCs). The authors also show that the chemotactic activity of SAA1α for monocytes and DCs is indirectly mediated by rapid chemokine induction, providing evidence that proposes a new level of regulation of leukocyte migration.",

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AU - Prete, Annalisa Del

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KW - Monocytes

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Chemokines as relay signals in human dendritic cell migration: Serum amyloid A kicks off chemotaxis

Abstract

Keywords

ASJC Scopus subject areas

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