TY - JOUR
T1 - Chemokines and Heart Disease
T2 - A Network Connecting Cardiovascular Biology to Immune and Autonomic Nervous Systems
AU - Dusi, Veronica
AU - Ghidoni, Alice
AU - Ravera, Alice
AU - De Ferrari, Gaetano M.
AU - Calvillo, Laura
PY - 2016
Y1 - 2016
N2 - Among the chemokines discovered to date, nineteen are presently considered to be relevant in heart disease and are involved in all stages of cardiovascular response to injury. Chemokines are interesting as biomarkers to predict risk of cardiovascular events in apparently healthy people and as possible therapeutic targets. Moreover, they could have a role as mediators of crosstalk between immune and cardiovascular system, since they seem to act as a "working-network" in deep linkage with the autonomic nervous system. In this paper we will describe the single chemokines more involved in heart diseases; then we will present a comprehensive perspective of them as a complex network connecting the cardiovascular system to both the immune and the autonomic nervous systems. Finally, some recent evidences indicating chemokines as a possible new tool to predict cardiovascular risk will be described.
AB - Among the chemokines discovered to date, nineteen are presently considered to be relevant in heart disease and are involved in all stages of cardiovascular response to injury. Chemokines are interesting as biomarkers to predict risk of cardiovascular events in apparently healthy people and as possible therapeutic targets. Moreover, they could have a role as mediators of crosstalk between immune and cardiovascular system, since they seem to act as a "working-network" in deep linkage with the autonomic nervous system. In this paper we will describe the single chemokines more involved in heart diseases; then we will present a comprehensive perspective of them as a complex network connecting the cardiovascular system to both the immune and the autonomic nervous systems. Finally, some recent evidences indicating chemokines as a possible new tool to predict cardiovascular risk will be described.
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U2 - 10.1155/2016/5902947
DO - 10.1155/2016/5902947
M3 - Review article
AN - SCOPUS:84971278423
SN - 0962-9351
VL - 2016
JO - Mediators of Inflammation
JF - Mediators of Inflammation
M1 - 5902947
ER -