Characterization of IgD. II. Molecular forms of IgD in human B cells

G. Corte, G. Viale, E. Cosulich, A. Bargellesi, M. Ferrarini

Research output: Contribution to journalArticlepeer-review


Endogenous and surface labelling techniques were used on human lymphoid cells to characterize intracytoplasmic, membrane and secreted IgD. IgD synthesized by lymphocytes and inserted into the cell membrane displayed a single molecular form with the same mobility in sodium dodecyl sulphase polyacrylamide gel electrophoresis (SDS-PAGE) as the previously described slow migrating serum IgD1. Plasma cells produced and secreted IgD1 and another IgD corresponding to the faster-moving serum IgD2. Conversion of one molecular form into the other was never observed, thus indicating that neither molecule is a precursor or a degradation product of the other.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalScandinavian Journal of Immunology
Issue number3
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Immunology


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