Changing trends of splenectomy in hereditary spherocytosis: The experience of a reference Centre in the last 40 years

Cristina Vercellati; Anna Zaninoni; Anna P. Marcello; Elisa Fermo; Bruno Fattizzo; Juri A. Giannotta; Paola Bianchi; Alberto Zanella; Wilma Barcellini

doi:10.1111/bjh.18106

Changing trends of splenectomy in hereditary spherocytosis: The experience of a reference Centre in the last 40 years

Cristina Vercellati, Anna Zaninoni, Anna P. Marcello, Elisa Fermo, Bruno Fattizzo, Juri A. Giannotta, Paola Bianchi, Alberto Zanella, Wilma Barcellini

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the clinical/haematological characteristics of 446 patients with hereditary spherocytosis diagnosed in the last 40 years in a reference centre. The frequency of splenectomy decreased over time (44% before 1990 to 7% in 2011–2020), notwithstanding a confirmed good efficacy. Age at splenectomy progressively increased (63% in children before 1990 to 88% in patients aged ≥20 years in 2011–2020). Our real-life experience showed that even a fraction of patients in the trait/mild categories (19/92, 21%) were splenectomised, whilst 30/78 (38%) in the moderate/severe groups were not. Overall, these data pinpoint to the increasing awareness about post-splenectomy thromboses and infections.

Original language	English
Pages (from-to)	912-915
Journal	British Journal of Haematology
Volume	198
Issue number	5
DOIs	https://doi.org/10.1111/bjh.18106
Publication status	Published - 2022

Keywords

cholecystectomy
complications
hereditary spherocytosis
pregnancy
splenectomy

ASJC Scopus subject areas

Hematology

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10.1111/bjh.18106

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title = "Changing trends of splenectomy in hereditary spherocytosis: The experience of a reference Centre in the last 40 years",

abstract = "We describe the clinical/haematological characteristics of 446 patients with hereditary spherocytosis diagnosed in the last 40 years in a reference centre. The frequency of splenectomy decreased over time (44% before 1990 to 7% in 2011–2020), notwithstanding a confirmed good efficacy. Age at splenectomy progressively increased (63% in children before 1990 to 88% in patients aged ≥20 years in 2011–2020). Our real-life experience showed that even a fraction of patients in the trait/mild categories (19/92, 21%) were splenectomised, whilst 30/78 (38%) in the moderate/severe groups were not. Overall, these data pinpoint to the increasing awareness about post-splenectomy thromboses and infections.",

keywords = "cholecystectomy, complications, hereditary spherocytosis, pregnancy, splenectomy",

author = "Cristina Vercellati and Anna Zaninoni and Marcello, {Anna P.} and Elisa Fermo and Bruno Fattizzo and Giannotta, {Juri A.} and Paola Bianchi and Alberto Zanella and Wilma Barcellini",

note = "Funding Information: Role of the funding source: This study was supported by RC 2020 Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico. Publisher Copyright: {\textcopyright} 2022 British Society for Haematology and John Wiley & Sons Ltd",

year = "2022",

doi = "10.1111/bjh.18106",

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T2 - The experience of a reference Centre in the last 40 years

AU - Vercellati, Cristina

AU - Zaninoni, Anna

AU - Marcello, Anna P.

AU - Fermo, Elisa

AU - Fattizzo, Bruno

AU - Giannotta, Juri A.

AU - Bianchi, Paola

AU - Zanella, Alberto

AU - Barcellini, Wilma

N1 - Funding Information: Role of the funding source: This study was supported by RC 2020 Fondazione IRCCS Ca′ Granda Ospedale Maggiore Policlinico. Publisher Copyright: © 2022 British Society for Haematology and John Wiley & Sons Ltd

PY - 2022

Y1 - 2022

N2 - We describe the clinical/haematological characteristics of 446 patients with hereditary spherocytosis diagnosed in the last 40 years in a reference centre. The frequency of splenectomy decreased over time (44% before 1990 to 7% in 2011–2020), notwithstanding a confirmed good efficacy. Age at splenectomy progressively increased (63% in children before 1990 to 88% in patients aged ≥20 years in 2011–2020). Our real-life experience showed that even a fraction of patients in the trait/mild categories (19/92, 21%) were splenectomised, whilst 30/78 (38%) in the moderate/severe groups were not. Overall, these data pinpoint to the increasing awareness about post-splenectomy thromboses and infections.

AB - We describe the clinical/haematological characteristics of 446 patients with hereditary spherocytosis diagnosed in the last 40 years in a reference centre. The frequency of splenectomy decreased over time (44% before 1990 to 7% in 2011–2020), notwithstanding a confirmed good efficacy. Age at splenectomy progressively increased (63% in children before 1990 to 88% in patients aged ≥20 years in 2011–2020). Our real-life experience showed that even a fraction of patients in the trait/mild categories (19/92, 21%) were splenectomised, whilst 30/78 (38%) in the moderate/severe groups were not. Overall, these data pinpoint to the increasing awareness about post-splenectomy thromboses and infections.

KW - cholecystectomy

KW - complications

KW - hereditary spherocytosis

KW - pregnancy

KW - splenectomy

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Changing trends of splenectomy in hereditary spherocytosis: The experience of a reference Centre in the last 40 years

Abstract

Keywords

ASJC Scopus subject areas

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