TY - GEN
T1 - Changes of mitochondria and relocation of the apoptosis-inducing factor during apoptosis
AU - Scovassi, A. Ivana
AU - Soldani, Cristiana
AU - Veneroni, Paola
AU - Bottone, Maria Grazia
AU - Pellicciari, Carlo
PY - 2009/8
Y1 - 2009/8
N2 - During apoptosis, apoptosis-inducing factor (AIF) is released from the mitochondrial intermembrane space to the cytosol and to the nucleus. We analyzed AIF in HeLa cells driven to apoptosis by either etoposide or actinomycin D, and we observed changes in the structure and function of mitochondria as well as the translocation of cytochrome c and AIF from mitochondria to the nucleus in early apoptosis. In cells with fragmented chromatin (i.e., in late apoptosis), the immunolabeling for AIF appeared to be distinct from chromatin, being mainly confined to mitochondria.
AB - During apoptosis, apoptosis-inducing factor (AIF) is released from the mitochondrial intermembrane space to the cytosol and to the nucleus. We analyzed AIF in HeLa cells driven to apoptosis by either etoposide or actinomycin D, and we observed changes in the structure and function of mitochondria as well as the translocation of cytochrome c and AIF from mitochondria to the nucleus in early apoptosis. In cells with fragmented chromatin (i.e., in late apoptosis), the immunolabeling for AIF appeared to be distinct from chromatin, being mainly confined to mitochondria.
KW - AIF
KW - Apoptosis
KW - Cytochrome c
KW - Mitochondria
UR - http://www.scopus.com/inward/record.url?scp=69149101823&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69149101823&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.04707.x
DO - 10.1111/j.1749-6632.2009.04707.x
M3 - Conference contribution
C2 - 19723032
AN - SCOPUS:69149101823
SN - 9781573317375
VL - 1171
T3 - Annals of the New York Academy of Sciences
SP - 12
EP - 17
BT - Annals of the New York Academy of Sciences
ER -