Cervicovaginal shedding of TT virus in HIV-infected women

Silvia Calcaterra, Maria S. Zaniratti, Diego Serraino, Mario Peroni, Isabella Abbate, Giuseppina Cappiello, Pierluca Piselli, Catia Pavia, Giovanni Rezza, Giuseppe Ippolito, Maria R. Capobianchi

Research output: Contribution to journalArticlepeer-review


Objective: TT virus (TTV) is frequently detected in the serum and in other body fluids of humans. Recently TTV-specific deoxyribonucleic acid has been detected in cervical specimens from apparently healthy women and in seminal fluid, suggesting that sexual transmission may be common. Study Design/Methods: TT virus-deoxyribonucleic acid prevalence was assessed in paired samples of blood and cervical smears from 110 human immunodeficiency virus-positive women. Detection and typing of human papillomavirus (HPV) present in cervical smears was also performed. Results: The prevalence of TTV-deoxyribonucleic acid in cervical smears was 16.4%, without significant difference (p = 0.81) between HPV-positive (18.6%) and -negative (14.9%) samples. The distribution of high/middle and low-risk HPV types was similar in TTV-positive and -negative samples. On the contrary, women with multiple HPV infections had a significantly higher TTV-deoxylibonucleic acid prevalence (60.0%) than HPV-negative women (p = 0.04). Conclusions: TT virus excretion in the female genital tract of human immunodeficiency virus-infected women is common, further supporting sexual transmission of this virus.

Original languageEnglish
Pages (from-to)343-345
Number of pages3
JournalJournal of Human Virology
Issue number6
Publication statusPublished - 2001


  • Cervical smear
  • Sexual transmission
  • TTV
  • Viral shedding

ASJC Scopus subject areas

  • Virology


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