Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

Antonello Spinelli; Marco Paolo Schiariti; Chiara Maria Grana; Mahila Esmeralda Ferrari; Marta Cremonesi; Federico Boschi

doi:10.1117/1.JBO.21.5.050502

Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

Antonello Spinelli, Marco Paolo Schiariti, Chiara Maria Grana, Mahila Esmeralda Ferrari, Marta Cremonesi, Federico Boschi

Research output: Contribution to journal › Article › peer-review

Abstract

We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of Y90-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.

Original language	English
Article number	050502
Journal	Journal of Biomedical Optics
Volume	21
Issue number	5
DOIs	https://doi.org/10.1117/1.JBO.21.5.050502
Publication status	Published - May 1 2016

Keywords

Beta minus radiopharmaceuticals
Brain tumor
Cerenkov luminescence imaging
Neurosurgery
Radioluminescence imaging

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics

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10.1117/1.JBO.21.5.050502

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abstract = "We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of Y90-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.",

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AU - Spinelli, Antonello

AU - Schiariti, Marco Paolo

AU - Grana, Chiara Maria

AU - Ferrari, Mahila Esmeralda

AU - Cremonesi, Marta

AU - Boschi, Federico

PY - 2016/5/1

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Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

Abstract

Keywords

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