Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

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We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of Y90-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.

Original languageEnglish
Article number050502
JournalJournal of Biomedical Optics
Issue number5
Publication statusPublished - May 1 2016


  • Beta minus radiopharmaceuticals
  • Brain tumor
  • Cerenkov luminescence imaging
  • Neurosurgery
  • Radioluminescence imaging

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics


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