Cerebrospinal fluid glutamate changes in functional movement disorders

Benedetta Demartini, Roberto William Invernizzi, Laura Campiglio, Tommaso Bocci, Andrea D’Arrigo, Andrea Arighi, Francesca Sciacca, Daniela Galimberti, Elio Scarpini, Orsola Gambini, Alberto Priori

Research output: Contribution to journalArticlepeer-review


The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.

Original languageEnglish
Article number37
Journalnpj Parkinson's Disease
Issue number1
Publication statusPublished - Dec 2020

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology


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