TY - JOUR
T1 - Cerebrospinal fluid glutamate changes in functional movement disorders
AU - Demartini, Benedetta
AU - Invernizzi, Roberto William
AU - Campiglio, Laura
AU - Bocci, Tommaso
AU - D’Arrigo, Andrea
AU - Arighi, Andrea
AU - Sciacca, Francesca
AU - Galimberti, Daniela
AU - Scarpini, Elio
AU - Gambini, Orsola
AU - Priori, Alberto
N1 - Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.
AB - The aim of this study was to assess cerebrospinal fluid (CSF) concentrations of specific amino acids using a high-performance liquid chromatography system in a sample of patients with functional movement disorders (FMDs) and in a sample of controls. CSF levels of glutamate were significantly lower in patients with FMD than in controls. This finding argues in favor of glutamatergic dysfunction in the pathophysiology of FMD.
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U2 - 10.1038/s41531-020-00140-z
DO - 10.1038/s41531-020-00140-z
M3 - Article
AN - SCOPUS:85097080732
SN - 2090-8083
VL - 6
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
IS - 1
M1 - 37
ER -