Cerebrospinal fluid analysis and the determination of oligoclonal bands

Matteo Gastaldi, Elisabetta Zardini, Rosaria Leante, Maddalena Ruggieri, Gianna Costa, Eleonora Cocco, Giovanna De Luca, Ivana Cataldo, Tiziana Biagioli, Clara Ballerini, Massimiliano Castellazzi, Enrico Fainardi, Paola Pettini, Mauro Zaffaroni, Debora Giunti, Elisabetta Capello, Gaetano Bernardi, Emilio Ciusani, Claudia Giannotta, Eduardo Nobile-OrazioElena Bazzigaluppi, Gabriella Passerini, Roberta Bedin, Patrizia Sola, Rinaldo Brivio, Guido Cavaletti, Arianna Sala, Antonio Bertolotto, Gaetano Desina, Maurizio A. Leone, Sara Mariotto, Sergio Ferrari, Andreina Paternoster, Davide Giavarina, Francesco Lolli, Diego Franciotta

Research output: Contribution to journalReview articlepeer-review


This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalNeurological Sciences
Publication statusPublished - Oct 1 2017


  • Intrathecal IgG synthesis
  • Isoelectric focusing
  • Laboratory diagnostics
  • Multiple sclerosis
  • Neuroimmunology

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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