Cerebrospinal fluid analysis and the determination of oligoclonal bands

Matteo Gastaldi; Elisabetta Zardini; Rosaria Leante; Maddalena Ruggieri; Gianna Costa; Eleonora Cocco; Giovanna De Luca; Ivana Cataldo; Tiziana Biagioli; Clara Ballerini; Massimiliano Castellazzi; Enrico Fainardi; Paola Pettini; Mauro Zaffaroni; Debora Giunti; Elisabetta Capello; Gaetano Bernardi; Emilio Ciusani; Claudia Giannotta; Eduardo Nobile-Orazio; Elena Bazzigaluppi; Gabriella Passerini; Roberta Bedin; Patrizia Sola; Rinaldo Brivio; Guido Cavaletti; Arianna Sala; Antonio Bertolotto; Gaetano Desina; Maurizio A. Leone; Sara Mariotto; Sergio Ferrari; Andreina Paternoster; Davide Giavarina; Francesco Lolli; Diego Franciotta

doi:10.1007/s10072-017-3034-2

Cerebrospinal fluid analysis and the determination of oligoclonal bands

Matteo Gastaldi, Elisabetta Zardini, Rosaria Leante, Maddalena Ruggieri, Gianna Costa, Eleonora Cocco, Giovanna De Luca, Ivana Cataldo, Tiziana Biagioli, Clara Ballerini, Massimiliano Castellazzi, Enrico Fainardi, Paola Pettini, Mauro Zaffaroni, Debora Giunti, Elisabetta Capello, Gaetano Bernardi, Emilio Ciusani, Claudia Giannotta, Eduardo Nobile-OrazioElena Bazzigaluppi, Gabriella Passerini, Roberta Bedin, Patrizia Sola, Rinaldo Brivio, Guido Cavaletti, Arianna Sala, Antonio Bertolotto, Gaetano Desina, Maurizio A. Leone, Sara Mariotto, Sergio Ferrari, Andreina Paternoster, Davide Giavarina, Francesco Lolli, Diego Franciotta

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Review article › peer-review

Abstract

This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

Original language	English
Pages (from-to)	217-224
Number of pages	8
Journal	Neurological Sciences
Volume	38
DOIs	https://doi.org/10.1007/s10072-017-3034-2
Publication status	Published - Oct 1 2017

Keywords

Intrathecal IgG synthesis
Isoelectric focusing
Laboratory diagnostics
Multiple sclerosis
Neuroimmunology

ASJC Scopus subject areas

Dermatology
Clinical Neurology
Psychiatry and Mental health

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10.1007/s10072-017-3034-2

Cite this

Gastaldi, M., Zardini, E., Leante, R., Ruggieri, M., Costa, G., Cocco, E., De Luca, G., Cataldo, I., Biagioli, T., Ballerini, C., Castellazzi, M., Fainardi, E., Pettini, P., Zaffaroni, M., Giunti, D., Capello, E., Bernardi, G., Ciusani, E., Giannotta, C., ... Franciotta, D. (2017). Cerebrospinal fluid analysis and the determination of oligoclonal bands. Neurological Sciences, 38, 217-224. https://doi.org/10.1007/s10072-017-3034-2

Gastaldi, M, Zardini, E, Leante, R, Ruggieri, M, Costa, G, Cocco, E, De Luca, G, Cataldo, I, Biagioli, T, Ballerini, C, Castellazzi, M, Fainardi, E, Pettini, P, Zaffaroni, M, Giunti, D, Capello, E, Bernardi, G, Ciusani, E, Giannotta, C, Nobile-Orazio, E, Bazzigaluppi, E, Passerini, G, Bedin, R, Sola, P, Brivio, R, Cavaletti, G, Sala, A, Bertolotto, A, Desina, G, Leone, MA, Mariotto, S, Ferrari, S, Paternoster, A, Giavarina, D, Lolli, F & Franciotta, D 2017, 'Cerebrospinal fluid analysis and the determination of oligoclonal bands', Neurological Sciences, vol. 38, pp. 217-224. https://doi.org/10.1007/s10072-017-3034-2

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AU - Gastaldi, Matteo

AU - Zardini, Elisabetta

AU - Leante, Rosaria

AU - Ruggieri, Maddalena

AU - Costa, Gianna

AU - Cocco, Eleonora

AU - De Luca, Giovanna

AU - Cataldo, Ivana

AU - Biagioli, Tiziana

AU - Ballerini, Clara

AU - Castellazzi, Massimiliano

AU - Fainardi, Enrico

AU - Pettini, Paola

AU - Zaffaroni, Mauro

AU - Giunti, Debora

AU - Capello, Elisabetta

AU - Bernardi, Gaetano

AU - Ciusani, Emilio

AU - Giannotta, Claudia

AU - Nobile-Orazio, Eduardo

AU - Bazzigaluppi, Elena

AU - Passerini, Gabriella

AU - Bedin, Roberta

AU - Sola, Patrizia

AU - Brivio, Rinaldo

AU - Cavaletti, Guido

AU - Sala, Arianna

AU - Bertolotto, Antonio

AU - Desina, Gaetano

AU - Leone, Maurizio A.

AU - Mariotto, Sara

AU - Ferrari, Sergio

AU - Paternoster, Andreina

AU - Giavarina, Davide

AU - Lolli, Francesco

AU - Franciotta, Diego

PY - 2017/10/1

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N2 - This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

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KW - Isoelectric focusing

KW - Laboratory diagnostics

KW - Multiple sclerosis

KW - Neuroimmunology

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JO - Neurological Sciences

JF - Neurological Sciences

ER -

Cerebrospinal fluid analysis and the determination of oligoclonal bands

Abstract

Keywords

ASJC Scopus subject areas

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