TY - JOUR
T1 - Central sensitization in photophobic and non-photophobic migraineurs
T2 - Possible role of retino nuclear way in the central sensitization process
AU - Lovati, Carlo
AU - Mariotti, C.
AU - Giani, L.
AU - D'Amico, D.
AU - Sinelli, A.
AU - De Angeli, F.
AU - Capiluppi, E.
AU - Bussone, G.
AU - Mariani, C.
PY - 2013
Y1 - 2013
N2 - The aim of the present study was to investigate the possible relationships between the presence of headache- related photophobia and migraine-associated allodynia - a hallmark of central sensitization - among patients with different migraine types. A sample of 456 migraineurs was studied. Our results showed that photophobia was present in a high proportion of patients, with similar figures in patients with episodic migraine or CM, and confirmed that the prevalence of allodynia was higher among CM patients than in those with episodic migraine. We found a clear association between migraine-related allodynia and photophobia only in CM patients. Overall, these findings suggest that light stimulation may contribute to central sensitization of pain pathways in migraineurs, possibly contributing to progression into chronic forms. The possible connections underlying this type of sensitization is offered by the recently published data on a nonimage- forming visual retino-thalamo-cortical pathway which may allow photic signals to converge on a thalamic region which is selectively activated during migraine headache.
AB - The aim of the present study was to investigate the possible relationships between the presence of headache- related photophobia and migraine-associated allodynia - a hallmark of central sensitization - among patients with different migraine types. A sample of 456 migraineurs was studied. Our results showed that photophobia was present in a high proportion of patients, with similar figures in patients with episodic migraine or CM, and confirmed that the prevalence of allodynia was higher among CM patients than in those with episodic migraine. We found a clear association between migraine-related allodynia and photophobia only in CM patients. Overall, these findings suggest that light stimulation may contribute to central sensitization of pain pathways in migraineurs, possibly contributing to progression into chronic forms. The possible connections underlying this type of sensitization is offered by the recently published data on a nonimage- forming visual retino-thalamo-cortical pathway which may allow photic signals to converge on a thalamic region which is selectively activated during migraine headache.
KW - Allodynia photophobia
KW - Central sensitization
KW - Chronic migraine (CM)
KW - Episodic migraine
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U2 - 10.1007/s10072-013-1369-x
DO - 10.1007/s10072-013-1369-x
M3 - Article
C2 - 23695062
AN - SCOPUS:84881224107
SN - 1590-1874
VL - 34
JO - Neurological Sciences
JF - Neurological Sciences
IS - SUPPL. 1
ER -