Central nervous system involvement in patients with HCV-related cryoglobulinemia

Laura Origgi, Massimo Vanoli, Annalisa Carbone, Miriam Grasso, Raffaella Scorza

Research output: Contribution to journalArticlepeer-review


Central nervous system involvement was rarely described in patients with mixed cryoglobulinemia (MC). Most cases were reported before 1991, so these patients were not tested for hepatitis C virus (HCV) infection. However, two cases of cerebral ischemia in patients with HCV-related MC were recently reported. We describe three patients with chronic HCV and cryoglobulinemia, who complained of mild neurologic symptoms (dizziness, equilibrium impairment, monolateral hyposthenia, and defective sensitivity) which can be ascribed to central nervous system involvement. In all of these patients, brain magnetic resonance imaging showed multiple small hyperintensities compatible with ischemic lesions.

Original languageEnglish
Pages (from-to)208-210
Number of pages3
JournalAmerican Journal of the Medical Sciences
Issue number3
Publication statusPublished - 1998


  • Central nervous system
  • Cryoglobulinemia
  • Hepatitis C virus

ASJC Scopus subject areas

  • Medicine(all)


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