Central Nervous System Complications in Children Receiving Chemotherapy or Hematopoietic Stem Cell Transplantation

Duccio Maria Cordelli; Riccardo Masetti; Daniele Zama; Francesco Toni; Ilaria Castelli; Emilia Ricci; Emilio Franzoni; Andrea Pession

doi:10.3389/fped.2017.00105

Central Nervous System Complications in Children Receiving Chemotherapy or Hematopoietic Stem Cell Transplantation

Duccio Maria Cordelli, Riccardo Masetti, Daniele Zama, Francesco Toni, Ilaria Castelli, Emilia Ricci, Emilio Franzoni, Andrea Pession

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

Therapy-related neurotoxicity greatly affects possibility of survival and quality of life of pediatric patients treated for cancer. Central nervous system (CNS) involvement is heterogeneous, varying from very mild and transient symptoms to extremely severe and debilitating, or even lethal syndromes. In this review, we will discuss the broad scenario of CNS complications and toxicities occurring during the treatment of pediatric patients receiving both chemotherapies and hematopoietic stem cell transplantation. Different types of complications are reviewed ranging from therapy related to cerebrovascular with a specific focus on neuroradiologic and clinical features.

Original language	English
Article number	105
Pages (from-to)	1-15
Journal	Frontiers in Pediatrics
Volume	5
DOIs	https://doi.org/10.3389/fped.2017.00105
Publication status	Published - May 15 2017

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AU - Cordelli, Duccio Maria

AU - Masetti, Riccardo

AU - Zama, Daniele

AU - Toni, Francesco

AU - Castelli, Ilaria

AU - Ricci, Emilia

AU - Franzoni, Emilio

AU - Pession, Andrea

PY - 2017/5/15

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AB - Therapy-related neurotoxicity greatly affects possibility of survival and quality of life of pediatric patients treated for cancer. Central nervous system (CNS) involvement is heterogeneous, varying from very mild and transient symptoms to extremely severe and debilitating, or even lethal syndromes. In this review, we will discuss the broad scenario of CNS complications and toxicities occurring during the treatment of pediatric patients receiving both chemotherapies and hematopoietic stem cell transplantation. Different types of complications are reviewed ranging from therapy related to cerebrovascular with a specific focus on neuroradiologic and clinical features.

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Central Nervous System Complications in Children Receiving Chemotherapy or Hematopoietic Stem Cell Transplantation

Abstract

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