TY - JOUR
T1 - Central effects of baroreceptor activation in humans
T2 - Attenuation of skeletal reflexes and pain perception
AU - Dworkin, B. R.
AU - Elbert, T.
AU - Rau, H.
AU - Birbaumer, N.
AU - Pauli, P.
AU - Droste, C.
AU - Brunia, C. H M
PY - 1994/7/5
Y1 - 1994/7/5
N2 - Activating the arterial baroreceptors blunts pain sensation and produces other forms of central nervous system inhibition in animals. These effects may be important to blood pressure regulation but have not been rigorously verified in humans. We describe (i) a noninvasive behaviorally unbiased method for baroreceptor stimulation and (ii) the application of this method to measurement of baroreceptor-mediated attenuation of pain perception and of the Achilles tendon reflex. The findings are relevant to basic mechanisms of blood pressure stabilization and cardiovascular reactivity and may also have implications for noncompliance with antihypertensive medications and for the pathophysiology of essential hypertension.
AB - Activating the arterial baroreceptors blunts pain sensation and produces other forms of central nervous system inhibition in animals. These effects may be important to blood pressure regulation but have not been rigorously verified in humans. We describe (i) a noninvasive behaviorally unbiased method for baroreceptor stimulation and (ii) the application of this method to measurement of baroreceptor-mediated attenuation of pain perception and of the Achilles tendon reflex. The findings are relevant to basic mechanisms of blood pressure stabilization and cardiovascular reactivity and may also have implications for noncompliance with antihypertensive medications and for the pathophysiology of essential hypertension.
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U2 - 10.1073/pnas.91.14.6329
DO - 10.1073/pnas.91.14.6329
M3 - Article
C2 - 8022781
AN - SCOPUS:0028301953
SN - 0027-8424
VL - 91
SP - 6329
EP - 6333
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 14
ER -