Abstract
Cellular volume of hepatocytes entrapped in alginate gel beads were evaluated under in vivo conditions in samples having different cell densities by applying mathematical models to the diffusion data obtained by magnetic resonance imaging (MRI). The calculated average volume is in good agreement with the values from the literature - being closer to the data relative to living tissue than to isolated cells. The non invasive characteristics of magnetic resonance imaging make this method particularly well suited to obtain information from the intact system.
| Original language | English |
|---|---|
| Pages (from-to) | 293-305 |
| Number of pages | 13 |
| Journal | Artificial Cells, Blood Substitutes, and Immobilization Biotechnology |
| Volume | 28 |
| Issue number | 4 |
| Publication status | Published - Jul 2000 |
Keywords
- Alginate
- Hepatocytes
- Magnetic resonance imaging
- Water diffusion
ASJC Scopus subject areas
- Biomedical Engineering
- Hematology
- Biotechnology
- Biomaterials