Cell death pathology: Perspective for human diseases

Massimiliano Agostini, Paola Tucci, Gerry Melino

Research output: Contribution to journalArticlepeer-review


Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - Oct 28 2011


  • AIDS
  • Apoptosis
  • Cancer
  • Immune system
  • Neurodegenerative diseases

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology


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