Cell death pathology: Perspective for human diseases

Massimiliano Agostini; Paola Tucci; Gerry Melino

doi:10.1016/j.bbrc.2011.09.081

Cell death pathology: Perspective for human diseases

Massimiliano Agostini, Paola Tucci, Gerry Melino

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.

Original language	English
Pages (from-to)	451-455
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	414
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2011.09.081
Publication status	Published - Oct 28 2011

Keywords

AIDS
Apoptosis
Cancer
Immune system
Neurodegenerative diseases

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Molecular Biology

Access to Document

10.1016/j.bbrc.2011.09.081

Cite this

@article{e10794cd7f2a4ea3b346b6a88bb707b1,

title = "Cell death pathology: Perspective for human diseases",

abstract = "Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.",

keywords = "AIDS, Apoptosis, Cancer, Immune system, Neurodegenerative diseases",

author = "Massimiliano Agostini and Paola Tucci and Gerry Melino",

year = "2011",

month = oct,

day = "28",

doi = "10.1016/j.bbrc.2011.09.081",

language = "English",

volume = "414",

pages = "451--455",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Cell death pathology

T2 - Perspective for human diseases

AU - Agostini, Massimiliano

AU - Tucci, Paola

AU - Melino, Gerry

PY - 2011/10/28

Y1 - 2011/10/28

N2 - Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.

AB - Apoptosis, a genetically regulated form of cell death with distinct biochemical and morphological features, plays a relevant physiological and pathological role in the organism, being pivotal in the maintenance of tissue development and homeostasis in the adult as well as in the regulation of immune responses. Deregulation of this process causes several human disorders including cancer, autoimmune and neurodegenerative diseases. Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies.

KW - AIDS

KW - Apoptosis

KW - Cancer

KW - Immune system

KW - Neurodegenerative diseases

UR - http://www.scopus.com/inward/record.url?scp=80054884802&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054884802&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2011.09.081

DO - 10.1016/j.bbrc.2011.09.081

M3 - Article

C2 - 21964290

AN - SCOPUS:80054884802

SN - 0006-291X

VL - 414

SP - 451

EP - 455

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 3

ER -

Cell death pathology: Perspective for human diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this