Cell-cycle molecules in mesothelioma: An overview

E. P. Spugnini, M. Campioni, A. D'Avino, G. Caruso, G. Citro, Alfonso Baldi

Research output: Contribution to journalArticlepeer-review


Cell cycle progression is mediated by a group of proteins named cyclins that activate a highly conserved family of protein kinases, the cyclin-dependent kinases (CDKs). CDKs are also regulated by related proteins called cdk inhibitors, grouped into two families: the INK4 inhibitors (p16, p15, p19 and p18) and the Cip/Kip inhibitors (p21, p27). Moreover, several tumour suppressor genes (such as Retinoblastoma gene and p53 gene) are implicated in the regulation of the molecular mechanism of cell division. Several studies report the importance of cell cycle regulator proteins in the pathogenesis and the prognosis of mesothelioma. This article will review the most recent data from the literature about the expression and the diagnostic and prognostic significance of cell cycle molecules in mesothelioma.

Original languageEnglish
Pages (from-to)443-449
Number of pages7
JournalJournal of Experimental and Clinical Cancer Research
Issue number4
Publication statusPublished - Dec 2007


  • INK4 inhibitors
  • Mesothelioma
  • p21
  • p53
  • Rb2

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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