Celiac disease in patients with sporadic and inherited cardiomyopathies and in their relatives

Tarcisio Not, Elena Faleschini, Alberto Tommasini, Alessandra Repetto, Michele Pasotti, Valentina Baldas, Andrea Spano, Daniele Sblattero, Roberto Marzari, Carlo Campana, Antonello Gavazzi, Luigi Tavazzi, Federico Biagi, Gino Roberto Corazza, Alessandro Ventura, Eloisa Arbustini

Research output: Contribution to journalArticlepeer-review


Aims: To investigate celiac disease (CD) and related co-morbidity in patients with familial and sporadic cardiomyopathy and in their relatives. Methods and results: We screened anti-human-tissue-transglutaminase (IgA and IgG anti-h-tTG) and anti-endomysial antibodies (AEAs) in 238 consecutive adult patients with inherited or sporadic dilated cardiomyopathy (DCM), 418 relatives, and 2000 healthy blood donors. HLADQ2-DQ8 was tested in tTG-positive subjects. The IgA-tTG-positive patients with cardiomyopathy underwent duodenal biopsy. Twenty-six subjects were tTG-positive: five DCM patients (2.1%), two of 28 (7.1%) and three of 390 (0.7%) relatives with and without echocardiographic abnormalities respectively, and 16 controls (0.8%). Twenty-two of 26 subjects were AEA-positive, and 25 HLA-positive. Of the five patients with cardiomyopathy and biopsy-proven CD, four suffered iron-deficiency anaemia. Two CD-positive DCM patients and two tTG-positive relatives were from families with inherited disease in which CD did not co-segregate with DCM. Conclusions: The higher prevalence of CD in patients with sporadic or inherited DCM, and of tTG-positive serology in relatives with echocardiographic abnormalities, suggests that immune-mediated mechanisms are active in subsets of patients/families. However, gluten intolerance cannot be considered causative since CD seems to be associated but not co-segregated with DCM in familial cases.

Original languageEnglish
Pages (from-to)1455-1461
Number of pages7
JournalEuropean Heart Journal
Issue number15
Publication statusPublished - Aug 2003


  • Celiac disease
  • Dilated cardiomyopathy
  • Tissue-transglutaminase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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