Celiac disease: histology-differential diagnosis-complications. A practical approach

Vincenzo Villanacci, Alessandro Vanoli, Giuseppe Leoncini, Giovanni Arpa, Tiziana Salviato, Luca Reggiani Bonetti, Carla Baronchelli, Luca Saragoni, Paola Parente

Research output: Contribution to journalReview articlepeer-review


Celiac disease is a multi-factorial chronic inflammatory intestinal disease, characterized by malabsorption resulting from mucosal injury after ingestion of wheat gluten or related rye and barley proteins. Inappropriate T-cell-mediated immune response against ingested gluten in genetically predisposed people, leads to characteristic histological lesions, as villous atrophy and intraepithelial lymphocytosis. Nevertheless, celiac disease is a comprehensive diagnosis with clinical, serological and genetic characteristics integrated with histological features. Biopsy of duodenal mucosa remains the gold standard in the diagnosis of celiac disease with the recognition of the spectrum of histological changes and classification of mucosa damage based on updated Corazza-Villanacci system. Appropriate differential diagnosis evaluation and clinical context also for the diagnosis of complications is, moreover, needed for correct histological features interpretation and clinical management.

Original languageEnglish
Pages (from-to)186-196
Number of pages11
Issue number3
Publication statusPublished - Sept 1 2020


  • celiac disease
  • gluten
  • small bowel
  • sprue

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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