CDX2 expression in cutaneous metastatic carcinomas and extramammary Paget's disease

Viviana Lora, Jean Kanitakis

Research output: Contribution to journalArticlepeer-review


Background: CDX2 is a gene involved in the regulation of intestinal cell proliferation/differentiation. It is considered specific for enterocytes and has been used for the diagnosis of primary and metastatic colon adenocarcinoma. The aim of this study was to assess the usefulness of CDX2 in the diagnosis of cutaneous metastatic tumors and extramammary Paget's disease. Materials and Methods: The immunohistochemical expression of CDX2 was studied in 68 cutaneous metastatic tumors of various origins and 14 specimens of extramammary Paget's disease. Results: CDX2 expression was found in 3/6 metastases of colon adenocarcinoma, 111 metastasis of urothelial carcinoma and 112 extramammary Paget's disease. Conclusion: CDX2 appears to be specific for cutaneous metastases from intestinal and urothelial carcinomas and is a useful diagnostic marker of these tumors. However, its sensitivity is modest, and we advocate its use in conjunction with additional immunohistochemical markers. CDX2 seems useful for the diagnosis of extramammary Paget's disease associated with an underlying colorectal tumor.

Original languageEnglish
Pages (from-to)5033-5037
Number of pages5
JournalAnticancer Research
Issue number12
Publication statusPublished - Dec 2009


  • CDX2
  • Cutaneous metastases
  • Extramammary Paget's disease
  • Immunohistochemistry
  • Skin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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