TY - JOUR
T1 - cDNA cloning of turtle prion protein
AU - Simonic, Tatjana
AU - Duga, Stefano
AU - Strumbo, Bice
AU - Asselta, Rosanna
AU - Ceciliani, Fabrizio
AU - Ronchi, Severino
PY - 2000/3/3
Y1 - 2000/3/3
N2 - Cloning of the cDNA coding for the 270-residue turtle prion protein is reported. It represents the most remote example thus far described. The entire coding region is comprised in a single exon, while a large intron interrupts the 5' UTR. The common structural features of the known prion proteins are all conserved in turtle PrP, whose identity degree to mammalian and avian proteins is about 40 and 58%, respectively. The most intriguing feature, unique to the turtle prion, is the presence of an EF-hand Ca2+ binding motif in the C-terminal half of the protein. Copyright (C) 2000 Federation of European Biochemical Societies.
AB - Cloning of the cDNA coding for the 270-residue turtle prion protein is reported. It represents the most remote example thus far described. The entire coding region is comprised in a single exon, while a large intron interrupts the 5' UTR. The common structural features of the known prion proteins are all conserved in turtle PrP, whose identity degree to mammalian and avian proteins is about 40 and 58%, respectively. The most intriguing feature, unique to the turtle prion, is the presence of an EF-hand Ca2+ binding motif in the C-terminal half of the protein. Copyright (C) 2000 Federation of European Biochemical Societies.
KW - cDNA cloning
KW - EF-hand Ca binding motif
KW - Gene organization
KW - Reptile prion protein
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U2 - 10.1016/S0014-5793(00)01232-1
DO - 10.1016/S0014-5793(00)01232-1
M3 - Article
C2 - 10708751
AN - SCOPUS:0034598968
SN - 0014-5793
VL - 469
SP - 33
EP - 38
JO - FEBS Letters
JF - FEBS Letters
IS - 1
ER -