TY - JOUR
T1 - CD99 immunoreactivity in gastrointestinal and pulmonary neuroendocrine tumours
AU - Pelosi, G.
AU - Fraggetta, Filippo
AU - Sonzogni, Angelica
AU - Fazio, Nicola
AU - Cavallon, Alessandra
AU - Viale, Giuseppe
PY - 2000
Y1 - 2000
N2 - Although considered a specific marker for Ewing's sarcoma/peripheral neuroectodermal tumour, the MIC2 gene product (CD99) has been immunolocalised in a variety of human tumours. The present study evaluated immunohistochemically the prevalence of CD99 expression in a series of 68 neuroendocrine tumours of different gastrointestinal and pulmonary sites. We now report on membrane and/or granular cytoplasmic immunoreactivity in 25% of these tumours, independent of their anatomical sites. In lung neuroendocrine tumours, CD99 was preferentially confined to typical carcinoids (P=0.009). A statistically significant relationship was observed between the number of CD99 positive cells but not the immunostaining patterns and the presence of local invasion and/or distant metastases (P
AB - Although considered a specific marker for Ewing's sarcoma/peripheral neuroectodermal tumour, the MIC2 gene product (CD99) has been immunolocalised in a variety of human tumours. The present study evaluated immunohistochemically the prevalence of CD99 expression in a series of 68 neuroendocrine tumours of different gastrointestinal and pulmonary sites. We now report on membrane and/or granular cytoplasmic immunoreactivity in 25% of these tumours, independent of their anatomical sites. In lung neuroendocrine tumours, CD99 was preferentially confined to typical carcinoids (P=0.009). A statistically significant relationship was observed between the number of CD99 positive cells but not the immunostaining patterns and the presence of local invasion and/or distant metastases (P
KW - CD99 antigen
KW - Cell-to-cell adhesion
KW - Immunohistochemistry
KW - Neuroendocrine tumours
KW - Proliferative activity
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U2 - 10.1007/s004280000240
DO - 10.1007/s004280000240
M3 - Article
C2 - 11037347
AN - SCOPUS:0033825878
SN - 0945-6317
VL - 437
SP - 270
EP - 274
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
IS - 3
ER -