CD5 positive B lymphocytes in seronegative juvenile arthritis

A. Martini, M. Massa, F. De Benedetti, S. Viola, G. Neirotti, R. G. Burgio

Research output: Contribution to journalArticlepeer-review


We investigated the levels of circulating CD5+ B cells in 43 patients with seronegative, HLA-B27 negative juvenile arthritis, 7 patients with juvenile dermatomyositis (DM) and 10 children with systemic lupus erythematosus (SLE). We found that CD5+ B cell levels were high in juvenile arthritis (p <0.01), normal in juvenile DM and decreased in SLE (p <0.01) compared to 33 age matched controls. In juvenile arthritis, the increase of CD5+ B cells appeared to be independent of disease activity and was present in all the onset types except in a subset of patients with late onset pauciarthritis.

Original languageEnglish
Pages (from-to)932-935
Number of pages4
JournalJournal of Rheumatology
Issue number7
Publication statusPublished - 1990


  • CD5+ B lymphocytes
  • juvenile arthritis

ASJC Scopus subject areas

  • Immunology
  • Rheumatology


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